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. 2018 Sep 25;16(1):192.
doi: 10.1186/s12957-018-1493-4.

Early decrease in postoperative serum albumin predicts severe complications in patients with colorectal cancer after curative laparoscopic surgery

Yong Wang  1 , Honggang Wang  1 , Jianguo Jiang  1 , Xiaofei Cao  2 , Qinghong Liu  3
Affiliations

Early decrease in postoperative serum albumin predicts severe complications in patients with colorectal cancer after curative laparoscopic surgery

Yong Wang et al. World J Surg Oncol. .

Abstract

Background: Postoperative severe complications are always associated with prolonged hospital stays, increased economic burdens, and poor prognoses in patients with colorectal cancer (CRC). This present study aimed to investigate potential risk factors including serum albumin (Alb) for severe complications in CRC patients.

Methods: Eligible patients with primary CRC undergoing elective laparoscopic colectomy from July 2015 to July 2017 were included. Postoperative severe complications were defined as grade III and IV according to the Clavien-Dindo classification. ∆Alb was defined as (preoperative Alb - nadir Alb within POD2)/preoperative Alb × 100%. The baseline characteristics, intraoperative data, and laboratory data were obtained from the database for the analysis. Univariate and multivariate logistic regression analyses were utilized for the assessment of the association between risk factors and postoperative severe complications. The predictive value of ∆Alb for postoperative severe complications was evaluated by receiver operating characteristic (ROC) curve analysis.

Results: A total of 193 patients were finally included in the analysis data set, of which 38 (19.7%) patients had postoperative severe complications. In the final multivariate logistic regression analysis, ∆Alb was the only independent factor associated with postoperative severe complications (OR 1.66, 95%CI 1.18-2.33, p = 0.003). The area under the curve (AUC) of ∆Alb was 0.916, with the sensitivity and specificity of 0.842 and 0.858 (p < 0.001).

Conclusions: The ∆Alb was an independent risk factor for severe complications in CRC patients after curative laparoscopic surgery.

Keywords: Albumin; Colorectal cancer; Postoperative complications; Predictor.

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Conflict of interest statement

Ethics approval and consent to participate

This study protocol was approved by the Medical Institutional Ethics Committee of Jiangsu province. All patients included were required to offer written informed consent.

Consent for publication

Not applicable.

Competing interests

The authors’ declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Flow chart of the cases analyzed
Fig. 2
Fig. 2
The predictive value of ∆Alb for postoperative severe complications by ROC analysis. AUC 0.916, cutoff value 17.3%, sensitivity 0.842, specificity 0.858, p < 0.001. Alb albumin, ROC receiver operating characteristics, AUC area under the curve
See this image and copyright information in PMC

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