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. 2018 Sep 10:11:5607-5619.
doi: 10.2147/OTT.S175566. eCollection 2018.

Podoplanin-positive cancer-associated fibroblasts predict poor prognosis in lung cancer patients

Guoming Hu  1 , Kefang Zhong  1 , Wei Chen  1 , Shimin Wang  2 , Liming Huang  1
Affiliations

Podoplanin-positive cancer-associated fibroblasts predict poor prognosis in lung cancer patients

Guoming Hu et al. Onco Targets Ther. .

Abstract

Background: Cancer-associated fibroblasts (CAFs) are a heterogeneous population, and different subpopulations play differential roles in tumor microenvironment. However, the prognostic role of podoplanin-positive CAFs in human lung cancer still remains controversial.

Methods: Herein, we performed a meta-analysis including 12 published studies with 1,802 patients identified from PubMed and EBSCO to assess the prognostic impact of podoplanin-positive CAFs in lung cancer patients.

Results: We found that podoplanin+ fibroblast infiltration significantly decreased overall survival (OS), disease-free survival (DFS), and progression-free survival in patients. In stratified analyses, podoplanin+ fibroblast infiltration was significantly associated with worse OS and DFS in both squamous cell carcinoma and adenocarcinoma of lung. In addition, high density of podoplanin-positive CAFs significantly correlated with unfavorable clinicopathological features such as lymph node metastasis, and lymphatic, vascular, and pleural invasion of patients.

Conclusion: Podoplanin+ fibroblast infiltration leads to worse clinical outcome in lung cancer patients, implicating that it is a valuable prognostic biomarker and targeting it may have a potential for effective treatment.

Keywords: lung cancer; meta-analysis; podoplanin-positive cancer-associated fibroblasts; worse outcome.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Forest plots describing HR of the association between podoplanin+ fibroblast infiltration and OS in lung cancer patients. Note: Weights are from random-effects analysis. Abbreviation: OS, overall survival.
Figure 2
Figure 2
Stratified analyses describing HRs of the association between podoplanin+ fibroblast infiltration and OS. Note: Weights are from random-effects analysis. Abbreviation: OS, overall survival.
Figure 3
Figure 3
Forest plots describing HR of the association between podoplanin+ fibroblast infiltration and DFS and PFS in lung cancer patients. Note: Weights are from random-effects analysis. Abbreviations: DFS, disease-free survival; PFS, progression-free survival.
Figure 4
Figure 4
Forest plots indicating ORs of the association between podoplanin+ fibroblast infiltration and clinicopathological features such as lymph node metastasis of lung cancer. Note: Weights are from random-effects analysis.
See this image and copyright information in PMC

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