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. 2018 Sep 12:11:1835-1847.
doi: 10.2147/JPR.S159729. eCollection 2018.

Prevalence of central and peripheral neuropathic pain in patients attending pain clinics in Spain: factors related to intensity of pain and quality of life

Inmaculada Failde  1   2 , María Dueñas  2   3 , Maria Victoria Ribera  4 , Rafael Gálvez  5 , Juan A Mico  2   6   7 , Alejandro Salazar  2   3 , Helena de Sola  1   2 , Concepción Pérez  8
Affiliations

Prevalence of central and peripheral neuropathic pain in patients attending pain clinics in Spain: factors related to intensity of pain and quality of life

Inmaculada Failde et al. J Pain Res. .

Erratum in

Abstract

Background: The objective of the study was to estimate the prevalence of pure central neuropathic pain (CNP) and peripheral neuropathic pain (PNP) among patients attending pain clinics in Spain. The study also aimed to analyze factors associated with pain intensity and quality of life (QoL).

Methods: A cross-sectional study was performed including 53 patients with pure CNP and 281 with pure PNP attending in 104 pain clinics in Spain. The revised grading system proposed in 2008 to determine a definite, probable or possible diagnosis of NP was used. Pain features, psychological variables and QoL were assessed. Descriptive, bivariate and multivariate analyses were performed.

Results: The prevalence of pure CNP and PNP amongst neuropathic pain patients was 2.4% (95% CI: 1.7;3.1) and 12.9% (95% CI: 1.5;14.3), respectively. Comorbid anxiety, depression or sleep disorders were high in both groups, but higher in CNP patients (51.1%, 71.4%, respectively). Pain intensity in PNP patients was associated with the presence of depression and sleep disturbances. However, in CNP patients, it was related with pain in the lower limbs. The impairment of QoL was greater in CNP patients than in PNP patients; pain location, presence of depression and sleep disturbance were the factors that most negatively affected QoL. Among PNP patients, women and those with higher pain intensity had worse QoL.

Conclusion: Pain intensity and QoL are affected by different factors in patients suffering from CNP or PNP. Identifying these factors could serve to guide therapeutic strategies and improve the QoL of patients.

Keywords: central neuropathic pain; pain intensity; peripheral neuropathic pain; quality of life.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Diagnostic labels. Abbreviations: CNP, central neuropathic pain; PNP, peripheral neuropathic pain.
Figure 2
Figure 2
Dimensions of the EQ-5D. Note: *p<0.05; **p<0.01. Abbreviation: EQ-5D, EuroQol-5 Dimensions.
Figure 3
Figure 3
Raw OR of the diagnostics related to the likelihood of having definite CNP diagnosis. Note: Other diagnostics includes spinal cord compression, post-surgical pain, tumors, spinal arteriovenous malformation, unspecified cause. Abbreviations: CNP, central neuropathic pain; OR, odds ratios.
Figure 4
Figure 4
Raw OR of the diagnostics related to the likelihood of having definite PNP diagnosis. Note: Other diagnostics includes post-traumatic, post-radiotherapy, and post-chemotherapy. Abbreviations: PNP, peripheral neuropathic pain; OR, odds ratios.
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