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Review
. 2018 Apr-Jun;7(2):47-55.
doi: 10.4103/GMIT.GMIT_10_18. Epub 2018 May 2.

Outcome and Management of Uterine Leiomyosarcoma Treated Following Surgery for Presumed Benign Disease: Review of Literature

Tanitra Tantitamit  1 , Kuan-Gen Huang  2   3 , Manatsawee Manopunya  4 , Chih-Feng Yen  2   3
Affiliations
Review

Outcome and Management of Uterine Leiomyosarcoma Treated Following Surgery for Presumed Benign Disease: Review of Literature

Tanitra Tantitamit et al. Gynecol Minim Invasive Ther. 2018 Apr-Jun.

Abstract

Uterine leiomyosarcoma (uLMS) is a rare and aggressive cancer, usually diagnosed incidentally at the time of myomectomy or hysterectomy. There have been concerns for several years about the fact that the inadvertent disruption of occult uLMS may have a negative impact on patient outcome. This study reviews the outcome and management of patients with a diagnosis of uLMS after surgery for presumed benign disease. We conducted a literature search in which 47 published English-language articles were obtained for evaluation. A total of 23 studies with outcomes data were included. It is evidenced that patients who underwent surgery with tumor disruption resulted in poorer outcomes compared with en bloc tumor, especially by power morcellation. The power morcellation was associated with an increased risk of recurrence, shorten time to recurrence, and upstage after re-exploration. Early re-exploration and surgical staging are appreciated for better prognosis and may alter postoperative treatment. We also updated on the incidence and preoperative evaluation to assess the risk of patient and give an effective counseling.

Keywords: Hysterectomy; myomectomy; occult leiomyosarcoma; prognosis.

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Conflict of interest statement

There are no conflicts of interest.

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References

    1. Bhave Chittawar P, Franik S, Pouwer AW, Farquhar C. Minimally invasive surgical techniques versus open myomectomy for uterine fibroids. Cochrane Database Syst Rev. 2014;10:CD004638. - PMC - PubMed
    1. Singh SS, Scott S, Bougie O, Leyland N, Leyland N, Wolfman W, et al. SOGC Clinical Practice-Gynaecology Committee. Technical update on tissue morcellation during gynaecologic surgery: Its uses, complications, and risks of unsuspected malignancy. J Obstet Gynaecol Can. 2015;37:68–81. - PubMed
    1. D'Angelo E, Prat J. Uterine sarcomas: A review. Gynecol Oncol. 2010;116:131–9. - PubMed
    1. Pritts EA, Parker WH, Brown J, Olive DL. Outcome of occult uterine leiomyosarcoma after surgery for presumed uterine fibroids: A systematic review. J Minim Invasive Gynecol. 2015;22:26–33. - PubMed
    1. Updated Laparoscopic Uterine Power Morcellation in Hysterectomy and Myomectomy: FDA Safety Communication. 2014. [Last accessed on 2018 Feb 16]. Available from: https://www.fda.gov/MedicalDevices/ProductsandMedicalProcedures/Surgerya... .