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. 2018 Sep;61(5):590-597.
doi: 10.5468/ogs.2018.61.5.590. Epub 2018 Aug 28.

Minimal deviation adenocarcinoma (adenoma malignum) of the uterine cervix: clinicopathological analysis of 17 cases

Min Hee Lee  1 , Eun Soo Kim  1 , Min Chul Choi  1 , Jin-Hyung Heo  2 , Ja-Hyun Jang  3 , Sang Geun Jung  1 , Hyun Park  1 , Won Duk Joo  1 , Chan Lee  1 , Je Ho Lee  1
Affiliations

Minimal deviation adenocarcinoma (adenoma malignum) of the uterine cervix: clinicopathological analysis of 17 cases

Min Hee Lee et al. Obstet Gynecol Sci. 2018 Sep.

Abstract

Objective: The aim of this study was to evaluate the clinicopathological features of minimal deviation adenocarcinoma (MDA) and to analyze its prognostic factors.

Methods: We retrospectively analyzed the medical records of 17 patients who were diagnosed with MDA at a single institution between January 2005 and December 2015.

Results: The median age of the patients was 47.7 years (33-75 years). MDA was diagnosed in 7 patients (41.2%) before performing definitive surgery. Stage IB disease was diagnosed in 12 patients (70.6%) and advanced stage disease (stage II: 3, stage III: 2) in 5. MDA was incidentally diagnosed following hysterectomy for benign conditions in 6 patients. Adjuvant therapy was administered to 13 patients (76.5%). During median follow-up over 33.6 months (7-99 months), 11 patients (64.7%) showed no evidence of disease, 6 (35.3%) showed persistent or recurrent disease and 5 died of the disease. Peutz-Jeghers syndrome was not suspected in any patient, and no mutation was detected in the 3 patients who underwent genetic testing. Univariate analysis showed that advanced stage disease (P=0.016) and lymphovascular space invasion (P=0.002) demonstrated a statistically significant association with poor overall survival (OS) rates. Advanced stage disease continued to show a significant association with poor OS rates (hazard ratio, 2.92; 95% confidence interval, 1.097-7.746; P=0.032) even after multivariate analysis.

Conclusion: Early diagnosis is important to manage MDA. Clinicians should consider MDA among the differential diagnoses in patients with a suspicious clinical presentation even with negative cervical screening tests.

Keywords: Cervical cancer; Minimal deviation adenocarcinoma; Peutz-Jeghers syndrome; Prognostic factors.

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Conflict of interest statement

Conflict of interest: No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1. (A) Kaplan-Meier curve showing the overall survival rate based on stages of minimal deviation adenocarcinoma (P=0.016). (B) Kaplan-Meier curve showing the overall survival rate based on lymphovascular space invasion (P=0.002).
See this image and copyright information in PMC

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