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. 2018 Dec;7(12):785-787.
doi: 10.1002/psp4.12353. Epub 2018 Oct 16.

Model-Informed Precision Dosing at the Bedside: Scientific Challenges and Opportunities

Ron J Keizer  1 , Rob Ter Heine  2 , Adam Frymoyer  3 , Lawrence J Lesko  4 , Ranvir Mangat  1 , Srijib Goswami  1
Affiliations

Model-Informed Precision Dosing at the Bedside: Scientific Challenges and Opportunities

Ron J Keizer et al. CPT Pharmacometrics Syst Pharmacol. 2018 Dec.

Abstract

The development of model-informed precision dosing (MIPD) tools, especially in the form of native or web-based applications to be used at the bedside, has garnered marked attention in recent years. Their potential clinical benefit can be large, but it should be ensured that such tools make optimal use of available clinical data and have adequate predictive ability. Unique scientific challenges specific to MIPD remain, which may require adaptation of commonly used diagnostics in pharmacometrics.

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Figures

Figure 1
Figure 1
Proposed workflow for model‐informed precision dosing (MIPD) tools at the bedside.
See this image and copyright information in PMC

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