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. 2018 Sep;23(38):1700642.
doi: 10.2807/1560-7917.ES.2018.23.38.1700642.

Large outbreak of mumps virus genotype G among vaccinated students in Norway, 2015 to 2016

Lamprini Veneti  1   2 , Katrine Borgen  1 , Kaja Sverdrup Borge  1 , Kostas Danis  2   3 , Margrethe Greve-Isdahl  1 , Kirsten Konsmo  1 , Gro Njølstad  4 , Svein Arne Nordbø  5   6 , Kari Stidal Øystese  7 , Rikard Rykkvin  1   8 , Eli Sagvik  9 , Øystein Rolandsen Riise  1
Affiliations

Large outbreak of mumps virus genotype G among vaccinated students in Norway, 2015 to 2016

Lamprini Veneti et al. Euro Surveill. 2018 Sep.

Abstract

From 6 September 2015-May 2016, a large mumps outbreak occurred among vaccinated students in Norway. A case was defined as a person presenting with a clinical mumps infection, notified between 1 September 2015 and 30 June 2016. Confirmed cases had positive laboratory confirmation and probable cases had an epidemiological link; PCR-positive specimens were genotyped. A total of 232 cases were notified (230 confirmed) with median age of 23 years (range 4-81) and 61% were male. Of 68 (30%) confirmed cases that were genotyped, 66 were genotype G and associated with the outbreak. Cases that had received two doses of the measles-mumps-rubella (MMR) vaccine had reduced risk of hospitalisation (adjusted relative risk (aRR): 0.14; 95%CI: 0.03-0.57), mumps-related orchitis (aRR: 0.21; 95% CI: 0.08-0.55) and severe outcome (aRR: 0.25; 95% CI: 0.10-0.62) compared with those unvaccinated. A third dose of the vaccine was offered to approximately 1,300 fully vaccinated close contacts and subsequently reported cases decreased. This large outbreak, occurring among predominately vaccinated students, suggests the current genotype A vaccine offers suboptimal protection against mumps genotype G. We recommend maintaining high vaccination coverage and offering the vaccine to all unvaccinated individuals.

Keywords: Norway; genotype G; measles-mumps-rubella (MMR) vaccine; mumps; outbreak; students.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure 1
Figure 1
Number of reported mumps cases by week of onset and place of infection, Norway, September 2015–May 2016 (n = 232 cases)
Figure 2
Figure 2
Place of infection of reported mumps cases in Norway, September 2015–May 2016 (n = 223)
Figure 3
Figure 3
Distribution of mumps reported cases by age and measles-mumps-rubella (MMR) vaccination status, Norway, September 2015–May 2016 (n = 232 cases)
See this image and copyright information in PMC

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