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. 1986 Oct;6(10):3531-6.
doi: 10.1128/mcb.6.10.3531-3536.1986.

Overproduction of protein p53 contributes to simian virus 40-mediated transformation

D Michalovitz, D Eliyahu, M Oren

Overproduction of protein p53 contributes to simian virus 40-mediated transformation

D Michalovitz et al. Mol Cell Biol. 1986 Oct.

Abstract

The possible involvement of p53 overproduction in simian virus 40 (SV40)mediated transformation was studied by using the rat embryo fibroblast focus formation assay. Transformation by wild-type SV40 was enhanced two- to threefold by cotransfection of a plasmid overexpressing mouse p53. More significantly, such a plasmid could partially complement a transformation-defective deletion mutant of SV40. Hence, the ability of SV40 T antigen to induce high p53 levels may indeed be directly relevant to the viral transforming potential.

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