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Review
. 2018 Sep 25;6(4):83.
doi: 10.3390/medsci6040083.

Ischemic Heart Disease during Acute Exacerbations of COPD

Rosa Malo de Molina  1 , Silvia Aguado  2 , Carlos Arellano  3 , Manuel Valle  4 , Piedad Ussetti  5
Affiliations
Review

Ischemic Heart Disease during Acute Exacerbations of COPD

Rosa Malo de Molina et al. Med Sci (Basel). .

Abstract

Patients with chronic obstructive pulmonary disease (COPD) have a higher risk of acute cardiovascular events, and around 30% die from cardiovascular diseases. Recent data suggest an increased risk of myocardial infarction in the following days of a severe exacerbation of COPD. Disruption in the balance during the exacerbation with tachycardia, increased inflammation and systemic oxidative stress as well as some other factors may confer an increased risk of subsequent cardiovascular events. A number of investigations may be useful to an early diagnosis, including electrocardiography, imaging techniques and blood test for biomarkers. Some drugs that have changed prognosis in the cardiovascular setting such as cardioselective beta-blockers may be underused in patients with COPD despite its demonstrated benefits. This review focuses on several aspects of exacerbation of COPD and cardiovascular events including epidemiology, possible mechanism, diagnosis and treatment.

Keywords: beta-blockers; cardiovascular; chronic obstructive pulmonary disease; exacerbation; myocardial infarction; treatment.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Potential factors contributing to acute ischemic heart disease in exacerbations of COPD. IHD: ischemic heart disease.
See this image and copyright information in PMC

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