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Case Reports
. 2018 Jan 26;42(5):302-305.
doi: 10.1080/01658107.2017.1419367. eCollection 2018 Oct.

Carboplatin-associated Cranial Neuropathy

Shanlee M Stevens  1 , Collin M McClelland  1 , John E Trusheim  2 , Michael S Lee  1
Affiliations
Case Reports

Carboplatin-associated Cranial Neuropathy

Shanlee M Stevens et al. Neuroophthalmology. .

Abstract

Carboplatin is a platinum-based chemotherapeutic agent used for the treatment of many solid tumors. Peripheral neuropathy is a common side effect; but, to our knowledge, ocular motor cranial neuropathies have not been reported in the literature. We describe a case of persistent third and fourth nerve palsies after systemic administration of intra-arterial carboplatin for glioblastoma multiforme. Neither nerve regained function after carboplatin was stopped.

Keywords: Carboplatin; cranial neuropathy; glioblastoma.

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Figures

Figure 1.
Figure 1.
Nine gaze montage demonstrates significant ptosis of the left upper eyelid along with poor elevation, adduction, and depression of the left eye consistent with a third nerve palsy. The lack of torsion indicating a fourth nerve palsy is not discernible on this figure.
See this image and copyright information in PMC

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