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. 2018 Aug 31:12:129-138.
doi: 10.2174/1874312901812010129. eCollection 2018.

Assessment of Mean Platelet Volume in Patients with Systemic Lupus Erythematosus

Lisandra Torres Hartmann  1 , Ana Paula Alegretti  1 , Alice Beatriz Mombach Pinheiro Machado  1 , Eduardo Ferreira Martins  2 , Rafael Mendonça da Silva Chakr  2 , Andrese Aline Gasparin  2 , Odirlei André Monticielo  2
Affiliations

Assessment of Mean Platelet Volume in Patients with Systemic Lupus Erythematosus

Lisandra Torres Hartmann et al. Open Rheumatol J. .

Abstract

Introduction: The Mean Platelet Volume (MPV) is a platelet activation biomarker that has been recently correlated with disease activity in SLE. We aimed to evaluate the MPV in patients with SLE comparing it with healthy individuals, to study the correlation between MPV and SLE Disease Activity Index (SLEDAI) in SLE patients and to analyze possible correlation between MPV and Erythrocyte Sedimentation Rate (ESR), C-Reactive Protein (CRP), and complement components C3 and C4.

Methods: This is a cross-sectional study in which 81 patients with SLE according to the American College of Rheumatology (ACR) diagnostic classification criteria and 58 healthy controls were included. Active disease was defined as SLEDAI>0.

Results: Patients with active SLE had decreased MPV when compared to inactive disease group (10.0±0.7fL vs. 10.7±1.0fL, p=0.005, respectively) and when compared to control group (10.9±1.0fL, p<0.001). Our study found a weak negative correlation between the SLEDAI and the MPV (r=-0.29, p=0.009). There was no correlation between MPV and CRP, ESR, C3 and C4. Also, no correlation between SLEDAI and CRP, ESR, C3 and C4 was found.

Conclusion: MPV decreases in patients with active SLE and is inversely correlated with SLEDAI.

Keywords: Autoimmunity; Biomarker; ESR; Mean platelet volume; Systemic lupus erythematosus; Systemic lupus erythematosus disease activity index.

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