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Case Reports
. 2018 Sep 6:2018:2651716.
doi: 10.1155/2018/2651716. eCollection 2018.

Very Rare Liver Neoplasm: Lymphoepithelioma-Like (LEL) Hepatocellular Carcinoma

Marcello Filotico  1 , Valentina Moretti  1 , Federica Floccari  2 , Alessandro D'Amuri  1
Affiliations
Case Reports

Very Rare Liver Neoplasm: Lymphoepithelioma-Like (LEL) Hepatocellular Carcinoma

Marcello Filotico et al. Case Rep Pathol. .

Abstract

A case of lymphoepithelioma-like (LEL) hepatobiliary carcinoma is reported. To date, only 89 cases of this rare neoplasm have been reported, with both hepatocellular and cholangiocellular histotype. The case reported here could be classified as LEL mixed hepatobiliary carcinoma (Hepato-Cholangio), a histotype not reported so far in the LEL variant.

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Figures

Figure 1
Figure 1
Surgical specimen: grossly polypoid neoformation with a large implant base.
Figure 2
Figure 2
(a) Fibrous band delimiting nodular area (HE 40x); (b) globular-polyhedral epithelial elements, with a pink, foliaceus, cytoplasm (HE 200x); (c) high mitotic activity, atypical mitotic figures (HE 200x); (d) trabecular arrangement with acinar formation (HE 200x).
Figure 3
Figure 3
(a, b, c) Abortive tubular formations (HE 200x); (d) massive lymphoid infiltration occupying sinusoidal space and disrupting the trabecular architecture (HE 100x).
Figure 4
Figure 4
(a) Lymphoid cells invading sinusoidal spaces (HE 200x); (b) diffuse lymphoid infiltration (HE 200x); (c) nodular lymphoid aggregate (HE 200x); (d) area of steatosis (HE 100x).
Figure 5
Figure 5
(a) Argyrophilic reticular network interrupted (Gomori 100x); (b) Gomori (400x); (c-d) Cytokeratin AE1-AE3—it is recognizable, though the trabecular architecture is altered ((c) 100x, (d) 200x).
Figure 6
Figure 6
(a-b) Hepatocyte diffuse and intense positivity (100x,200x); (c-d) TTF1, focal positivity (100x, 200x); (e-f) CK7 focal positivity (100x); (g-h) CK7 positivity in ductular structures (400x); (i-j) CK19 positivity in canalicular structures (100x, 200x); (k-l) αFP focal positivity (100x).
Figure 7
Figure 7
(a-b) CD10;(200x); (c) CD3; (d) CD4; (e) CD5; (f) CD8; (g-h) CD20; (i) CD138; (j) CD34 (100x).
See this image and copyright information in PMC

References

    1. Bosman F. T., Carneiro F., Hruban R. H., Theise N. D. WHO Classification of Tumours. 3rd. Lyon, France: IARC Press; 2010.
    1. Shirabe K., Matsumata T., Maeda T., Sadanaga N., Kuwano H., Sugimachi K. A long-term surviving patient with hepatocellular carcinoma including lymphocytes infiltration - A clinicopathological study. Hepato-Gastroenterology. 1995;42(6):996–1001. - PubMed
    1. Hsu H.-C., Chen C.-C., Huang G.-T., Lee P.-H. Clonal Epstein-Barr virus associated cholangiocarcinoma with lymphoepithelioma-like component. Human Pathology. 1996;27(8):848–850. doi: 10.1016/S0046-8177(96)90460-8. - DOI - PubMed
    1. Labgaa I., Stueck A., Ward S. C. Lymphoepithelioma-Like Carcinoma in Liver. The American Journal of Pathology. 2017;187(7):1438–1444. doi: 10.1016/j.ajpath.2017.02.022. - DOI - PubMed
    1. Hsu H., Chen C., Huang G., Lee P. Clonal epstein-barr virus associated cholangiocarcinoma with lymphoepithelioma-like component. Human Pathology. 1996;27(8):848–850. doi: 10.1016/S0046-8177(96)90460-8. - DOI - PubMed

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