Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Sep-Oct;9(5):299-303.
doi: 10.4103/idoj.IDOJ_81_18.

A Study of Cutaneous Adverse Drug Reactions in a Tertiary Care Center in Punjab

Niharika Jha  1 , Emy Alexander  2 , Bimal Kanish  2 , Dinesh K Badyal  3
Affiliations

A Study of Cutaneous Adverse Drug Reactions in a Tertiary Care Center in Punjab

Niharika Jha et al. Indian Dermatol Online J. 2018 Sep-Oct.

Abstract

Context: Cutaneous adverse drug eruptions are the most common adverse reactions attributed to drugs in which any type of skin reaction can be mimicked, induced, or aggravated.

Aims: To study the pattern of various types of cutaneous adverse drug reactions (CADRs), to find out the causative drug(s) involved and to determine the response to treatment and outcome in patients with CADRs.

Patients and methods: This prospective study was done in the department of dermatology. Patients with suspected drug rash, of either sex and all age groups were included in the study.

Statistical analysis: Frequencies and proportions were calculated using Chi-square test and t-test as the tests of significance. Data was analyzed using SPSS version 21.

Results: A total of 258 patients were enrolled in the study. The most common CADR observed in the study was exanthematous drug eruption in 42.63% patients followed by drug induced urticaria in 21.32% patients. Antimicrobials were the most common offending drugs in 64.73% of patients, followed by non-steroidal anti-inflammatory drugs (NSAIDs) in 15.50% patients. In the study, 12 patients (4.65%) were found to have severe cutaneous adverse drug reactions (SCADRs). Stevens-Johnson syndrome (SJS) - Toxic epidermal necrolysis (TEN) was the most common SCADR (50%) and antituberculous drugs were the most common causative group of drugs causing SCADRs.

Conclusion: The most common CADR observed in the study was exanthematous drug eruption and antimicrobials were the most common causative drugs.

Keywords: Antimicrobials; cutaneous adverse drug reactions; exanthematous drug eruption.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Exanthematous drug rash
Figure 2
Figure 2
Urticarial drug rash
Figure 3
Figure 3
Bullous fixed drug eruption
Figure 4
Figure 4
Steven–Johnson syndrome
Figure 5
Figure 5
Toxic epidermal necrolysis
Figure 6
Figure 6
Acute generalized exanthematous pustulosis
See this image and copyright information in PMC

References

    1. Saha A, Das NK, Hazra A, Gharami RC, Chowdhury SN, Datta PK. Cutaneous adverse drug reaction profile in a tertiary care out patient setting in Eastern India. Indian J Pharmacol. 2012;44:792–7. - PMC - PubMed
    1. Bhatia A, Kanish B, Ziauddin M, Badyal D, Kartik Cutaneous adverse drug reaction monitoring in a tertiary care teaching hospital. Clin Res. 2013;5:60–5.
    1. Nayak S, Acharjya B. Adverse cutaneous drug reaction. Indian J Dermatol. 2008;53:2–8. - PMC - PubMed
    1. Choon S, Lai N. An epidemiological and clinical analysis of cutaneous adverse drug reactions seen in a tertiary hospital in Johor, Malaysia. Indian J Dermatol Venereol Leprol. 2012;78:734–9. - PubMed
    1. Pudukadan D, Thappa DM. Adverse cutaneous drug reactions: Clinical pattern and causative agents in a tertiary care center in South India. Indian J Dermatol Venereol Leprol. 2004;70:20–4. - PubMed