Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Feb 14;4(1):25-27.
doi: 10.1016/j.gendis.2017.02.003. eCollection 2017 Mar.

Aerobic glycolysis and high level of lactate in cancer metabolism and microenvironment

Bo Jiang  1
Affiliations
Review

Aerobic glycolysis and high level of lactate in cancer metabolism and microenvironment

Bo Jiang. Genes Dis. .

Abstract

Metabolic abnormalities is a hallmark of cancer. About 100 years ago, Nobel laureate Otto Heinrich Warburg first described high rate of glycolysis in cancer cells. Recently more and more novel opinions about cancer metabolism supplement to this hypothesis, consist of glucose uptake, lactic acid generation and secretion, acidification of the microenvironment and cancer immune evasion. Here we briefly review metabolic pathways generating lactate, and discuss the function of higher lactic acid in cancer microenvironments.

Keywords: Aerobic glycolysis; Cancer metabolism; Glucose metabolism; Immune escape; Lactate.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Roma-Rodrigues C., Fernandes A.R., Baptista P.V. Exosome in tumour microenvironment: overview of the crosstalk between normal and cancer cells. BioMed Res Int. 2014;2014:179486. - PMC - PubMed
    1. Schlereth S.L., Refaian N., Iden S., Cursiefen C., Heindl L.M. Impact of the prolymphangiogenic crosstalk in the tumor microenvironment on lymphatic cancer metastasis. BioMed Res Int. 2014;2014:639058. - PMC - PubMed
    1. Kroemer G., Pouyssegur J. Tumor cell metabolism: cancer's Achilles' heel. Cancer Cell. Jun 2008;13(6):472–482. - PubMed
    1. Altenberg B., Greulich K.O. Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes. Genomics. 2004;84(6):1014–1020. - PubMed
    1. Martins S.F., Amorim R., Viana-Pereira M. Significance of glycolytic metabolism-related protein expression in colorectal cancer, lymph node and hepatic metastasis. BMC Cancer. 2016;16:535. - PMC - PubMed

LinkOut - more resources