Association analysis of FTO gene polymorphisms and obesity risk among Egyptian children and adolescents

doi:10.1016/j.gendis.2017.06.002

. 2017 Jul 4;4(3):170-175.

doi: 10.1016/j.gendis.2017.06.002. eCollection 2017 Sep.

Association analysis of FTO gene polymorphisms and obesity risk among Egyptian children and adolescents

Samar Samir Abdelmajed¹, Mohamed Youssef², Moushira Erfan Zaki³, Naglaa Abu-Mandil Hassan³, Somaia Ismail⁴

Affiliations

¹ October University for Modern Sciences and Arts (MSA), Giza, Egypt.
² Organic chemistry Department, Faculty of science, Cairo University, Egypt.
³ Biological Anthropology Department, Medical Research Division, National Research Centre, Egypt.
⁴ Medical Molecular Genetics Department, Human Genetics and Genome Research Division, National Research Centre, Giza, Egypt.

PMID: 30258920
PMCID: PMC6146173
DOI: 10.1016/j.gendis.2017.06.002

Association analysis of FTO gene polymorphisms and obesity risk among Egyptian children and adolescents

Samar Samir Abdelmajed et al. Genes Dis. 2017.

. 2017 Jul 4;4(3):170-175.

doi: 10.1016/j.gendis.2017.06.002. eCollection 2017 Sep.

Authors

Samar Samir Abdelmajed¹, Mohamed Youssef², Moushira Erfan Zaki³, Naglaa Abu-Mandil Hassan³, Somaia Ismail⁴

Affiliations

¹ October University for Modern Sciences and Arts (MSA), Giza, Egypt.
² Organic chemistry Department, Faculty of science, Cairo University, Egypt.
³ Biological Anthropology Department, Medical Research Division, National Research Centre, Egypt.
⁴ Medical Molecular Genetics Department, Human Genetics and Genome Research Division, National Research Centre, Giza, Egypt.

PMID: 30258920
PMCID: PMC6146173
DOI: 10.1016/j.gendis.2017.06.002

Abstract

Obesity is a common disorder that has a significant impact on human health as it may lead to many serious diseases and sometimes morbidity. Previous genome-wide association studies (GWAS) confirmed that there is a relationship between some variants in the first intron of the fat mass and obesity associated (FTO) gene and obesity in adults and children in different ethnic groups. In our study, the association of the FTO rs9939609 and rs17817449 variants with obesity was investigated in Egyptian children and adolescents. We examined rs9939609 and rs17817449 polymorphisms in 100 control and 100 obese cases, we used the restriction fragment length polymorphism (RFLP) technique to genotype the samples. The current study showed that there were no significant differences (P > 0.05) between the cases and controls in both variants of rs17817449 and rs9939609 polymorphisms. However, there were significant correlations between rs17817449 and cholesterol and between rs9939609 and LDL. In Current Study although the two variants (rs9939609 and rs17817449) didn't show an association with obesity, but there was a correlation between the lipid profile and these two variants.

Keywords: Children; Egyptians; Fat mass and obesity associated gene (FTO); Obesity; Variants.

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References

1. Kelly T., Yang W., Chen C.S. Global burden of obesity in 2005 and projections to 2030. Int J Obes. 2008;32(9):1431–1437. - PubMed
1. Patel A.V., Hildebrand J.S., Gapstur S.M. Body mass index and all-cause mortality in a large prospective cohort of white and black US adults. PLoS One. 2014;9(10) - PMC - PubMed
1. Atinmo T., Mirmiran P., Oyewole O.E. Breaking the poverty/malnutrition cycle in Africa and the Middle East. Nutr Rev. 2009;67(suppl 1):S40–S46. - PubMed
1. Ellabany E., Abel-Nasser M. Egypt Ministry of Health and Population, and WHO; 2006. Community Based Survey Study on Non Communicable Diseases and their Risk Factors. Egypt, 2005–2006, Tech. Rep.
1. World Health Organization . World Health Organization; 2010. World Health Statistics 2010.

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[1] Kelly T., Yang W., Chen C.S. Global burden of obesity in 2005 and projections to 2030. Int J Obes. 2008;32(9):1431–1437. - PubMed

[2] Kelly T., Yang W., Chen C.S. Global burden of obesity in 2005 and projections to 2030. Int J Obes. 2008;32(9):1431–1437. - PubMed

[3] Patel A.V., Hildebrand J.S., Gapstur S.M. Body mass index and all-cause mortality in a large prospective cohort of white and black US adults. PLoS One. 2014;9(10) - PMC - PubMed

[4] Patel A.V., Hildebrand J.S., Gapstur S.M. Body mass index and all-cause mortality in a large prospective cohort of white and black US adults. PLoS One. 2014;9(10) - PMC - PubMed

[5] Atinmo T., Mirmiran P., Oyewole O.E. Breaking the poverty/malnutrition cycle in Africa and the Middle East. Nutr Rev. 2009;67(suppl 1):S40–S46. - PubMed

[6] Atinmo T., Mirmiran P., Oyewole O.E. Breaking the poverty/malnutrition cycle in Africa and the Middle East. Nutr Rev. 2009;67(suppl 1):S40–S46. - PubMed

[7] Ellabany E., Abel-Nasser M. Egypt Ministry of Health and Population, and WHO; 2006. Community Based Survey Study on Non Communicable Diseases and their Risk Factors. Egypt, 2005–2006, Tech. Rep.

[8] Ellabany E., Abel-Nasser M. Egypt Ministry of Health and Population, and WHO; 2006. Community Based Survey Study on Non Communicable Diseases and their Risk Factors. Egypt, 2005–2006, Tech. Rep.

[9] World Health Organization . World Health Organization; 2010. World Health Statistics 2010.

[10] World Health Organization . World Health Organization; 2010. World Health Statistics 2010.

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Association analysis of FTO gene polymorphisms and obesity risk among Egyptian children and adolescents

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Association analysis of FTO gene polymorphisms and obesity risk among Egyptian children and adolescents

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