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. 2018 Sep 6:4:444-449.
doi: 10.1016/j.trci.2018.08.005. eCollection 2018.

Amyloid-associated increases in longitudinal report of subjective cognitive complaints

Rebecca E Amariglio  1   2 , Rachel F Buckley  2   3   4 , Elizabeth C Mormino  2   5 , Gad A Marshall  1   2 , Keith A Johnson  1   2   6 , Dorene M Rentz  1   2 , Reisa A Sperling  1   2
Affiliations

Amyloid-associated increases in longitudinal report of subjective cognitive complaints

Rebecca E Amariglio et al. Alzheimers Dement (N Y). .

Abstract

Introduction: To investigate whether baseline subjective cognitive complaints (SCCs) predict longitudinal decline on neuropsychological testing and whether SCC increases longitudinally, in the setting of high levels of amyloid burden.

Methods: Two hundred seventy-nine clinically normal older participants (mean age = 73.7 ± 6.1 years) from the Harvard Aging Brain Study, a cohort of community-dwelling individuals, were followed longitudinally (4.27 ± 1.35 years) with annual subjective memory questionnaires and neuropsychological assessment. 11C Pittsburgh compound-B positron emission tomography was used to measure cortical amyloid and to classify status (Aβ+/Aβ-) at baseline.

Results: Higher baseline SCC predicted more rapid cognitive decline on neuropsychological measures among those with elevated amyloid (t = -2.18, P < .0001). In addition, longitudinal report of SCC significantly increased over time, with SCC progression most pronounced among Aβ+ individuals (t = 2.24, P = .0005).

Discussion: SCC may inform risk for future cognitive decline and track progression of self-perceived decline, particularly in those along the AD trajectory, providing potentially important indicators of clinical meaningfulness in AD prevention trials.

Keywords: Amyloid; PET imaging; Preclinical Alzheimer's disease; Subjective cognitive decline.

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Figures

Fig. 1
Fig. 1
STIDA predicting PACC decline separated by Aβ group. Visit occurs on an annual basis. Abbreviations: PACC, Preclinical Alzheimer Cognitive Composite; SD, standard deviation; STIDA, Structured Telephone Interview for Dementia Assessment.
Fig. 2
Fig. 2
Greater endorsement on STIDA over the course of the study. Visit occurs on an annual basis. Abbreviation: STIDA, Structured Telephone Interview for Dementia Assessment.
Fig. 3
Fig. 3
Longitudinal STIDA by baseline Aβ group. Visit occurs on an annual basis. Abbreviations: STIDA, Structured Telephone Interview for Dementia Assessment; Aβ group, amyloid group.
See this image and copyright information in PMC

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