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Randomized Controlled Trial
. 2019;15(1):141-145.
doi: 10.1080/21645515.2018.1514227. Epub 2018 Sep 27.

Maternal transfer of anti HPV 6 and 11 antibodies upon immunization with the 9-valent HPV vaccine

Ana Maria Guevara  1 , Eugenio Suarez  2 , Alejandro Victoria  3 , Hextan Ys Ngan  4 , Angelica Lindén Hirschberg  5 , Edison Fedrizzi  6 , Oliver Bautista  7 , Christine Shields  7 , Amita Joshi  7 , Alain Luxembourg  7
Affiliations
Randomized Controlled Trial

Maternal transfer of anti HPV 6 and 11 antibodies upon immunization with the 9-valent HPV vaccine

Ana Maria Guevara et al. Hum Vaccin Immunother. 2019.

Abstract

Background: This exploratory analysis was conducted to characterize the level of HPV types 6/11 antibodies in peripartum maternal blood and in cord blood of infants born to women who received 9-valent HPV (9vHPV) vaccine or quadrivalent HPV (qHPV) vaccine in a pivotal efficacy study (V503-001, NCT 00543543).

Methods: A total of 21 mother-infant pairs had evaluable HPV 6/11 results available for analysis. HPV6/11 antibodies were assessed using competitive Luminex immunoassay. The distribution of the ratios of infant to mother anti-HPV antibodies (i.e., infant-anti-HPV/mother- anti-HPV) was summarized.

Results: All mothers and infants were seropositive to HPV 6 and HPV 11. Anti-HPV 6/11 geometric mean titers (GMTs) in peripartum maternal blood and in cord blood of infant born to study participants were highly correlated. A 100% of infants born to seropositive mothers were also seropositive. The GMT ratios of peripartum maternal blood vs. those in cord blood were HPV 6: 1.23 [0.43, 3.49] and HPV 11: 1.29 [0.54, 3.07] in the 9vHPV vaccine group and HPV 6: 1.33 [0.41, 4.29] and HPV 11: 1.19 [0.45, 3.13] in the qHPV vaccine group, respectively.

Conclusions: These results indicate that antibodies induced by the 9vHPV vaccine cross the placenta, which could potentially be beneficial against HPV6/11 infection and related disease such as recurrent respiratory papillomatosis.

Keywords: 9vHPV vaccine; clinical trial; geometric mean titers (GMTs); human papillomavirus; recurrent respiratory papillomatosis.

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Figures

Figure 1.
Figure 1.
Scatter plots of the mother- infant HPV cLIA data points (x = cord blood anti-HPV result, y = maternal serum anti-HPV result) by vaccine group. Pearson correlation coefficients of 0.94 and 0.93 were calculated for HPV 6 and 11 in the 9vHPV vaccine group and 0.99 and 0.77 for HPV 6 and 11 in the qHPV vaccine group.
See this image and copyright information in PMC

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