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. 1986 Nov;30(5):777-80.
doi: 10.1128/AAC.30.5.777.

Purification and properties of DNA gyrase from a fluoroquinolone-resistant strain of Escherichia coli

K Sato, Y Inoue, T Fujii, H Aoyama, M Inoue, S Mitsuhashi

Purification and properties of DNA gyrase from a fluoroquinolone-resistant strain of Escherichia coli

K Sato et al. Antimicrob Agents Chemother. 1986 Nov.

Abstract

Subunit A and B proteins of DNA gyrase were separately purified from fluoroquinolone-resistant Escherichia coli GN14181 (MIC of ofloxacin, 100 micrograms/ml) and susceptible strain KL-16. The supercoiling activities of reconstituted Ar+Br (r, resistant) and Ar+Bs (s, susceptible) were 250-fold more resistant to new fluoroquinolones than those of As+Bs and As+Br.

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