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Comment
. 2018 Sep 28;361(6409):1314-1315.
doi: 10.1126/science.aav0191.

How dormant cancer persists and reawakens

Julio A Aguirre-Ghiso  1
Affiliations
Comment

How dormant cancer persists and reawakens

Julio A Aguirre-Ghiso. Science. .
No abstract available

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Figures

None
Dormant DCC immune evasion and activation to form metastasis
This simplified model shows that microenvironmental cues, such as TSP-1, induce and maintain dormancy. Dormant DCCs down-regulate E-cadherin expression and up- regulate UPR activity, which results in MHC-I down-regulation and immune evasion from CD8+ T cells. Eventually, unpredictable changes in the host cause inflammation and other tissue-wide changes. Inflammation can recruit neutrophils to produce NETs and the associated proteases cause proteolytic processing of laminin-111 and TSP1 degradation. This causes α3β1 integ sin-mediated activation of dormant DCCs that proliferate to form metastasis.
See this image and copyright information in PMC

Comment on

  • Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice.
    Albrengues J, Shields MA, Ng D, Park CG, Ambrico A, Poindexter ME, Upadhyay P, Uyeminami DL, Pommier A, Küttner V, Bružas E, Maiorino L, Bautista C, Carmona EM, Gimotty PA, Fearon DT, Chang K, Lyons SK, Pinkerton KE, Trotman LC, Goldberg MS, Yeh JT, Egeblad M. Albrengues J, et al. Science. 2018 Sep 28;361(6409):eaao4227. doi: 10.1126/science.aao4227. Science. 2018. PMID: 30262472 Free PMC article.

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