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Comment

. 2018 Sep 28;361(6409):1314-1315.

doi: 10.1126/science.aav0191.

How dormant cancer persists and reawakens

Julio A Aguirre-Ghiso¹

Affiliations

Affiliation

¹ Division of Hematology and Oncology, Department of Medicine, Department of Otolaryngology, Tisch Cancer Institute, Black Family Stem Cell Institute, and Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. julio.aguirre-ghiso@mssm.edu.

PMID: 30262486
PMCID: PMC6415964
DOI: 10.1126/science.aav0191

Comment

How dormant cancer persists and reawakens

Julio A Aguirre-Ghiso. Science. 2018.

. 2018 Sep 28;361(6409):1314-1315.

doi: 10.1126/science.aav0191.

Author

Julio A Aguirre-Ghiso¹

Affiliation

¹ Division of Hematology and Oncology, Department of Medicine, Department of Otolaryngology, Tisch Cancer Institute, Black Family Stem Cell Institute, and Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. julio.aguirre-ghiso@mssm.edu.

PMID: 30262486
PMCID: PMC6415964
DOI: 10.1126/science.aav0191

No abstract available

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Figures

None — Dormant DCC immune evasion and activation to form metastasis
This simplified model shows that microenvironmental cues, such as TSP-1, induce and maintain dormancy. Dormant DCCs down-regulate E-cadherin expression and up- regulate UPR activity, which results in MHC-I down-regulation and immune evasion from CD8+ T cells. Eventually, unpredictable changes in the host cause inflammation and other tissue-wide changes. Inflammation can recruit neutrophils to produce NETs and the associated proteases cause proteolytic processing of laminin-111 and TSP1 degradation. This causes α3β1 integ sin-mediated activation of dormant DCCs that proliferate to form metastasis.

See this image and copyright information in PMC

Comment on

Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice.
Albrengues J, Shields MA, Ng D, Park CG, Ambrico A, Poindexter ME, Upadhyay P, Uyeminami DL, Pommier A, Küttner V, Bružas E, Maiorino L, Bautista C, Carmona EM, Gimotty PA, Fearon DT, Chang K, Lyons SK, Pinkerton KE, Trotman LC, Goldberg MS, Yeh JT, Egeblad M. Albrengues J, et al. Science. 2018 Sep 28;361(6409):eaao4227. doi: 10.1126/science.aao4227. Science. 2018. PMID: 30262472 Free PMC article.

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