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. 2018 Sep 17;12(Suppl 9):26.
doi: 10.1186/s12919-018-0113-1. eCollection 2018.

GAW20: methods and strategies for the new frontiers of epigenetics and pharmacogenomics

Nathan L Tintle  1 , David W Fardo  2 , Mariza de Andrade  3 , Stella Aslibekyan  4 , Julia N Bailey  5 , Justo Lorenzo Bermejo  6 , Rita M Cantor  7 , Saurabh Ghosh  8 , Philip Melton  9 , Xuexia Wang  10 , Jean W MacCluer  11 , Laura Almasy  12   13
Affiliations

GAW20: methods and strategies for the new frontiers of epigenetics and pharmacogenomics

Nathan L Tintle et al. BMC Proc. .

Abstract

GAW20 provided a platform for developing and evaluating statistical methods to analyze human lipid-related phenotypes, DNA methylation, and single-nucleotide markers in a study involving a pharmaceutical intervention. In this article, we present an overview of the data sets and the contributions analyzing these data. The data, donated by the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) investigators, included data from 188 families (N = 1105) which included genome-wide DNA methylation data before and after a 3-week treatment with fenofibrate, single-nucleotide polymorphisms, metabolic syndrome components before and after treatment, and a variety of covariates. The contributions from individual research groups were extensively discussed prior, during, and after the Workshop in groups based on discussion themes, before being submitted for publication.

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Conflict of interest statement

Not applicable.Not applicable.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

References

    1. Aslibekyan S, Almasy L, Province MA, Absher DM, Arnett DK. Data for GAW20: genome-wide DNA sequence variation and epigenome-wide DNA methylation before and after fenofibrate treatment in a family study of metabolic phenotypes. BMC Proc. 2018;12(Suppl 9). 10.1186/s12919-018-0114-0. - PMC - PubMed
    1. Kraja AT, An P, Lenzini P, Lin SJ, Williams C, Hicks JE, Daw EW, Province MA. Simulation of a medication and methylation effects on triglycerides in the Genetic Analysis Workshop 20. BMC Proc. 2018;12(Suppl 9). 10.1186/s12919-018-0115-z. - PMC - PubMed

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