doi: 10.1016/s0006-291x(86)80355-2.
Pyrimidine dimer dependent cleavage of single-stranded DNA by T4 UV endonuclease
- PMID: 3026375
- DOI: 10.1016/s0006-291x(86)80355-2
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Pyrimidine dimer dependent cleavage of single-stranded DNA by T4 UV endonuclease
Biochem Biophys Res Commun.
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Abstract
T4 UV endonuclease cleaves double- and single-stranded DNA with equal specificity for photo-pyrimidine dimers. Thus, the enzyme can be used for mapping and quantifying pyrimidine dimers in single-stranded DNA as well as in double-stranded DNA. Mapping of pyrimidine dimers shows that rates of UV-dimerization are not only affected by 5', 3' adjacent bases, but also by position within pyrimidine tracts. Di-pyrimidines at 3' ends of tracts are more photoreactive than those at 5' ends.
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