Conflicts of interest disclosure forms and management in critical care clinical practice guidelines

Waleed Alhazzani^{1

2}, Kimberley Lewis³, Roman Jaeschke^{3

4}, Bram Rochwerg^{3

4}, Morten Hylander Møller⁵, Laura Evans⁶, Kevin C Wilson⁷, Sheena Patel⁸, Craig M Coopersmith⁹, Maurizio Cecconi^{10

11}, Gordon Guyatt^{3

4}, Elie A Akl^{4

12}

Affiliations

¹ Department of Medicine, Division of Critical Care, St Joseph's Healthcare Hamilton, McMaster University, 50 Charlton Avenue, Hamilton, ON, L8N 4A6, Canada. alhazzaw@mcmaster.ca.
² Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Canada. alhazzaw@mcmaster.ca.
³ Department of Medicine, Division of Critical Care, St Joseph's Healthcare Hamilton, McMaster University, 50 Charlton Avenue, Hamilton, ON, L8N 4A6, Canada.
⁴ Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Canada.
⁵ Department of Intensive Care 4131, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
⁶ Division of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, USA.
⁷ Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
⁸ American College of Chest Physicians (CHEST), Glenview, IL, USA.
⁹ Department of Surgery and Emory Critical Care Center, Emory University, Atlanta, USA.
¹⁰ Humanitas Clinical and Research Center, Milan, Italy.
¹¹ Department of Biomedical Sciences, Humanitas University, Milan, Italy.
¹² Department of Internal Medicine, American University of Beirut, Beirut, Lebanon.

PMID: 30264380
DOI: 10.1007/s00134-018-5367-6

Review

Conflicts of interest disclosure forms and management in critical care clinical practice guidelines

Waleed Alhazzani et al. Intensive Care Med. 2018 Oct.

. 2018 Oct;44(10):1691-1698.

doi: 10.1007/s00134-018-5367-6. Epub 2018 Sep 27.

Authors

Affiliations

¹ Department of Medicine, Division of Critical Care, St Joseph's Healthcare Hamilton, McMaster University, 50 Charlton Avenue, Hamilton, ON, L8N 4A6, Canada. alhazzaw@mcmaster.ca.
² Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Canada. alhazzaw@mcmaster.ca.
³ Department of Medicine, Division of Critical Care, St Joseph's Healthcare Hamilton, McMaster University, 50 Charlton Avenue, Hamilton, ON, L8N 4A6, Canada.
⁴ Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Canada.
⁵ Department of Intensive Care 4131, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
⁶ Division of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, USA.
⁷ Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
⁸ American College of Chest Physicians (CHEST), Glenview, IL, USA.
⁹ Department of Surgery and Emory Critical Care Center, Emory University, Atlanta, USA.
¹⁰ Humanitas Clinical and Research Center, Milan, Italy.
¹¹ Department of Biomedical Sciences, Humanitas University, Milan, Italy.
¹² Department of Internal Medicine, American University of Beirut, Beirut, Lebanon.

PMID: 30264380
DOI: 10.1007/s00134-018-5367-6

Abstract

Background: Trustworthy clinical practice guidelines (CPGs) require identification and careful management of conflicts of interest (COIs) among all participants in the guideline development. Furthermore, COIs are more common than anticipated. However, there are no universally accepted methods to identify and manage COIs.

Objective: To describe and summarize the current COI disclosure forms and management policies in selected critical care professional societies that develop high-impact CPGs. In addition, we aim to provide suggestions to guideline developers on how to identify and manage different types of COIs.

Methods: We searched PubMed and MEDLINE for CPGs published between 2013 and 2018 in English language and addressed general critical care topics. We then ranked the CPGs according to the numbers of citations and selected the first five critical care professional societies that sponsored the guidelines. We obtained the most recent COI declaration forms and management policies. Two reviewers abstracted data on different types of COI in each of the disclosure forms and management policies.

Results: All selected professional critical care societies require that members declare direct financial COIs; four societies inquire specifically about intellectual COIs (involvement in primary research). Three out of five societies require members to disclose indirect institutional financial COIs; however, none inquire about other forms of institutional COI. We developed, by consensus, a streamlined framework to classify and manage different types of COIs.

Conclusion: The current COI disclosure forms of selected professional societies provide more attention to financial disclosures and COIs and less attention to detecting and managing intellectual COIs, while rarely addressing institutional COIs. We provide some suggestions for guideline developers on the classification and management of different COIs in the context of CPGs.

Keywords: Clinical practice guidelines; Conflict of interest; Critical care.

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References

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1. Schunemann HJ, Wiercioch W, Etxeandia I et al (2014) Guidelines 2.0: systematic development of a comprehensive checklist for a successful guideline enterprise. CMAJ 186(3):E123–E142 - DOI
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1. Schunemann HJ, Al-Ansary LA, Forland F et al (2015) Guidelines international network: principles for disclosure of interests and management of conflicts in guidelines. Ann Intern Med 163(7):548–553 - DOI

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Conflicts of interest disclosure forms and management in critical care clinical practice guidelines

Affiliations

Conflicts of interest disclosure forms and management in critical care clinical practice guidelines

Authors

Affiliations

Abstract

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical