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. 2018 Nov;7(11):5775-5788.
doi: 10.1002/cam4.1795. Epub 2018 Sep 27.

The incidence and survival of pancreatic cancer by histology, including rare subtypes: a nation-wide cancer registry-based study from Taiwan

Jeffrey S Chang  1 , Li-Tzong Chen  1   2   3   4 , Yan-Shen Shan  5   6 , Pei-Yi Chu  1   7   8 , Chia-Rung Tsai  1 , Hui-Jen Tsai  1   2   3
Affiliations

The incidence and survival of pancreatic cancer by histology, including rare subtypes: a nation-wide cancer registry-based study from Taiwan

Jeffrey S Chang et al. Cancer Med. 2018 Nov.

Abstract

Studies have indicated a significant rise in the incidence of pancreatic adenocarcinoma. However, the epidemiology of other rare histologic subtypes of pancreatic cancer is not well understood. This study analyzed the incidence and survival of pancreatic cancer in Taiwan by histologic subtype, sex, age group, and year of diagnosis. The incidence trends of pancreatic cancer in Taiwan from 2002 to 2013 were calculated using data from the Taiwan Cancer Registry. The survival of pancreatic cancer patients was assessed using the life-table method and Cox proportional hazards analysis. The incidence of pancreatic cancer increased from 4.62 per 100,000 in 2002 to 6.04 per 100,000 in 2013 in Taiwan. The most common histologic subtype of pancreatic cancer was adenocarcinoma followed by carcinoma and neuroendocrine tumors (NETs). Adenocarcinoma and NETs showed a rapid increase in incidence, while the incidences of other subtypes did not change significantly. Patients with adenocarcinoma showed a poor survival with a 5-year survival of 5.2%. Patients with endocrinomas, NETs, and lymphoma displayed a better survival than those with adenocarcinoma, with a 5-year survival ranging from 41.8% to 59.1%. The survival of adenocarcinoma, lymphoma, and NETs improved after the introduction of novel therapies. Understanding the risk factors and identifying the biomarkers for the early diagnosis of pancreatic cancer are important to prevent the development and improve the survival of pancreatic cancer.

Keywords: incidence; pancreatic cancer; survival.

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Figures

Figure 1
Figure 1
The annual age‐standardized incidence rate (cases per 100 000) of pancreatic cancers from 2002 to 2013 in Taiwan. (A) The annual age‐standardized incidence rate of pancreatic cancers in men, women, and both sexes from 2002 to 2013 in Taiwan. (B) The annual incidence rate of pancreatic cancer by histologic subtype. (C) The annual incidence rate of the rare histologic subtype of pancreatic cancer, including neuroendocrine tumors (NETs), endocrinomas, squamous cell carcinoma, lymphoma, small cell carcinoma, and sarcoma
Figure 2
Figure 2
The distribution of pancreatic cancers by age, sex, and histologic subtype. (A) The proportion of pancreatic cancers by age and sex from 2002 to 2013. (B) The distribution of pancreatic cancers by histologic subtypes from 2002 to 2013
Figure 3
Figure 3
The survival curves of pancreatic cancers by histologic subtypes in all, men and women diagnosed from 2002 to 2013 in Taiwan
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