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. 1986 Dec;102(12):731-3.

[Effect of beta-endorphin and myelopeptides on the cAMP level and proliferation of lymphocytes in vitro]

[Article in Russian]
A A Zozulia, E Patsakova, N V Kost, A M Ivanushkin, T L Voronkova
  • PMID: 3026514

[Effect of beta-endorphin and myelopeptides on the cAMP level and proliferation of lymphocytes in vitro]

[Article in Russian]
A A Zozulia et al. Biull Eksp Biol Med. 1986 Dec.

Abstract

Beta-endorphin (10(-11)-10(-9) M) has been shown to induce naloxone-independent depression of the proliferative activity of human peripheral lymphocytes (HL), stimulated by pokeweed mitogen without affecting PHA-stimulated HL proliferation. Beta-endorphin (10(-10)-10(-7) M) also caused changes in HL cAMP level, that were blocked by naloxone. Marked individual sensitivity to beta-endorphin effects has been noted. It has been also shown that a bone marrow preparation, stimulating antibody production (myelopeptides), causes naloxone-independent depression in the proliferative activity of HL, stimulated by PHA and pokeweed mitogen, as well as naloxone-blocked decrease in cAMP HL level. It has been concluded that beta-endorphin interacts with several types of opiate lymphocyte receptors and that opioids, contained in myelopeptides, are involved in the realization of myelopeptide effect on lymphocytes.

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