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Multicenter Study
. 2019 Apr 1;5(2):114-120.
doi: 10.1093/ehjqcco/qcy045.

Hospital readmission following takotsubo syndrome

Nathaniel R Smilowitz  1 , Anais Hausvater  1 , Harmony R Reynolds  1
Affiliations
Multicenter Study

Hospital readmission following takotsubo syndrome

Nathaniel R Smilowitz et al. Eur Heart J Qual Care Clin Outcomes. .

Abstract

Aims: Takotsubo syndrome (TTS) is characterized by transient left ventricular dysfunction with symptoms and electrocardiographic changes mimicking acute myocardial infarction (AMI). The objective of this study was to evaluate in-hospital death and hospital readmission in patients with TTS and to compare outcomes to patients with AMI.

Methods and results: Patients diagnosed with TTS and AMI were identified using the United States Nationwide Readmission Database from 2010 to 2014. In-hospital outcomes for the index admission, and rates and causes of 30 day readmissions were compared between TTS patients and AMI patients without TTS. Sixty-one thousand, four hundred, and twelve patients with TTS and 3 470 011 patients with AMI without TTS were identified. Patients with TTS were younger, more often women (89% vs. 41%), and less likely to have cardiovascular risk factors than AMI patients. Mortality during the index admission was lower in TTS compared with AMI (2.3% vs. 10.2%, P < 0.0001). Cardiogenic shock occurred at the same frequency (5.7%) with TTS or AMI. Among TTS survivors, 7132 patients (11.9%) were readmitted within 30 days, and mortality associated with readmission was 3.5%. The most common reason for readmission after TTS was heart failure (HF; 10.6% of readmissions).

Conclusion: Takotsubo syndrome is associated with substantial morbidity and mortality. Although outcomes are more favourable than AMI, approximately 2% of patients died in hospital and approximately 12% of survivors were readmitted within 30 days; HF was the most frequent indication for rehospitalization. Careful outpatient follow-up of TTS patients may be warranted to avoid readmissions.

Keywords: Acute coronary syndrome; Hospital readmission; Myocardial infarction; Readmission; Takotsubo syndrome.

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Figures

Figure 1
Figure 1
Proportion of patients with takotsubo syndrome and acute myocardial infarction with hospital readmission over time.
Figure 2
Figure 2
In-hospital outcomes and 30 day hospital readmissions in patients with takotsubo syndrome compared with acute myocardial infarction.
See this image and copyright information in PMC

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References

    1. Bybee KA, Prasad A.. Stress-related cardiomyopathy syndromes. Circulation 2008;118:397–409. - PubMed
    1. Templin C, Ghadri JR, Diekmann J, Napp LC, Bataiosu DR, Jaguszewski M. et al. Clinical features and outcomes of takotsubo (stress) cardiomyopathy. N Engl J Med 2015;373:929–938. - PubMed
    1. Lyon AR, Bossone E, Schneider B, Sechtem U, Citro R, Underwood SR. et al. Current state of knowledge on Takotsubo syndrome: a Position Statement from the taskforce on Takotsubo Syndrome of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail 2016;18:8–27. - PubMed
    1. Deshmukh A, Kumar G, Pant S, Rihal C, Murugiah K, Mehta JL.. Prevalence of takotsubo cardiomyopathy in the United States. Am Heart J 2012;164:66–71.e1. - PubMed
    1. Brinjikji W, El-Sayed AM, Salka S.. In-hospital mortality among patients with takotsubo cardiomyopathy: a study of the national inpatient sample 2008 to 2009. Am Heart J 2012;164:215–221. - PubMed

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