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Multicenter Study
. 2018 Sep 28;13(9):e0204333.
doi: 10.1371/journal.pone.0204333. eCollection 2018.

Impact of catheter-induced iatrogenic coronary artery dissection with or without postprocedural flow impairment: A report from a Japanese multicenter percutaneous coronary intervention registry

Takahiro Hiraide  1 , Mitsuaki Sawano  1 , Yasuyuki Shiraishi  1 , Ikuko Ueda  1 , Yohei Numasawa  2 , Shigetaka Noma  3 , Kouji Negishi  4 , Takahiro Ohki  5 , Shinsuke Yuasa  1 , Kentaro Hayashida  1 , Hiroaki Miyata  6 , Keiichi Fukuda  1 , Shun Kohsaka  1
Affiliations
Multicenter Study

Impact of catheter-induced iatrogenic coronary artery dissection with or without postprocedural flow impairment: A report from a Japanese multicenter percutaneous coronary intervention registry

Takahiro Hiraide et al. PLoS One. .

Abstract

Despite the ever-increasing complexity of percutaneous coronary intervention (PCI), the incidence, predictors, and in-hospital outcomes of catheter-induced coronary artery dissection (CICAD) is not well defined. In addition, there are little data on whether persistent coronary flow impairment after CICAD will affect clinical outcomes. We evaluated 17,225 patients from 15 participating hospitals within the Japanese PCI registry from January 2008 to March 2016. Associations between CICAD and in-hospital adverse cardiovascular events were evaluated using multivariate logistic regression. Outcomes of patients with CICAD with or without postprocedural flow impairment (TIMI flow ≤ 2 or 3, respectively) were analyzed. The population was predominantly male (79.4%; mean age, 68.2 ± 11.0 years); 35.6% underwent PCI for complex lesions (eg. chronic total occlusion or a bifurcation lesion.). CICAD occurred in 185 (1.1%), and its incidence gradually decreased (p < 0.001 for trend); postprocedural flow impairment was observed in 43 (23.2%). Female sex, complex PCI, and target lesion in proximal vessel were independent predictors (odds ratio [OR], 2.18; 95% confidence interval [CI], 1.53-3.10; OR, 2.19; 95% CI, 1.58-3.04; and OR, 1.55; 95% CI, 1.06-2.28, respectively). CICAD was associated with an increased risk of in-hospital adverse events (composite of new-onset cardiogenic shock and new-onset heart failure) regardless of postprocedural flow impairment (OR, 10.9; 95% CI, 5.30-22.6 and OR, 2.27; 95% CI, 1.20-4.27, respectively for flow-impaired and flow-recovered CICAD). In conclusion, CICAD occurred in roughly 1% of PCI cases; female sex, complex PCI, and proximal lesion were its independent risk factors. CICAD was associated with adverse in-hospital cardiovascular events regardless of final flow status. Our data implied that the appropriate selection of PCI was necessary for women with complex lesions.

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Conflict of interest statement

The authors have read the journal’s policy and have the following competing interests: Shun Kohsaka received an unrestricted research grant for Department of Cardiology, Keio University School of Medicine from Daiichi-Sankyo Japan. The other authors declare no conflict of interest. This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.

Figures

Fig 1
Fig 1. Study population flow diagram.
CICAD was occurred in 1.1% of study population. CICAD = catheter-induced coronary artery dissection; PCI = percutaneous coronary intervention.
Fig 2
Fig 2. Annual incidence of catheter-induced coronary artery dissection.
The annual incidence of CICAD was gradually decreasing in study period (p < 0.001 for trend with Cochran-Armitage test). CICAD = catheter-induced coronary artery dissection; PCI = percutaneous coronary intervention.
Fig 3
Fig 3. Predictors of catheter-induced coronary artery dissection.
Multivariable predictors of iatrogenic coronary artery dissection (CICAD). Adjusted OR (point estimate) and 95% CI (error bars) indicate the likelihood ratio of CICAD from logistic regression. OR > 1 indicates increased odds of CICAD. CICAD = catheter-induced coronary artery dissection; OR = odds ratio; PCI = percutaneous coronary intervention.
See this image and copyright information in PMC

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