Role of Zeb2/Sip1 in neuronal development
- PMID: 30266271
- DOI: 10.1016/j.brainres.2018.09.034
Role of Zeb2/Sip1 in neuronal development
Abstract
Zeb2 (Sip1, Zfhx1b) is a transcription factor that plays essential role in neuronal development. Sip1 mutation in humans was shown to cause Mowat-Wilson syndrome, a syndromic form of Hirschprung's disease. Affected individuals exhibit multiple severe neurodevelopmental defects. Zeb2 can act as both transcriptional repressor and activator. It controls expression of a wide number of genes that regulate various aspects of neuronal development. This review addresses the molecular pathways acting downstream of Zeb2 that cause brain development disorders.
Keywords: Brain development; Cortex; Hippocampus; Mowat-Wilson syndrome.
Copyright © 2018. Published by Elsevier B.V.
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