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. 1987 Feb 13;48(3):525-34.
doi: 10.1016/0092-8674(87)90203-0.

The c-Ha-ras oncogene and a tumor promoter activate the polyoma virus enhancer

C Wasylyk, J L Imler, J Perez-Mutul, B Wasylyk

The c-Ha-ras oncogene and a tumor promoter activate the polyoma virus enhancer

C Wasylyk et al. Cell. .

Abstract

A c-Ha-ras oncogene, to a lesser extent the c-Ha-ras proto-oncogene, and the tumor promoter 12-O-tetradecanoylphorbol-13-acetate activate the inactive polyoma virus (Py) enhancer in a myeloma cell line and the partially active Py enhancer in NIH 3T3 fibroblasts, but have no effect on the active Py enhancer in LMTK- fibroblasts. In addition, c-Ha-ras can stimulate the inactive Py enhancer in embryonal carcinoma F9 cells. c-Ha-ras activation in embryonal carcinoma cells does not appear to involve reversal of "E1A-like" inhibition of the enhancer. We suggest that modulation of cellular enhancer activity could play a key role in tumorigenesis by oncogenes.

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