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. 2018 Sep 29;18(1):315.
doi: 10.1186/s12887-018-1290-9.

Agreement test of transcutaneous bilirubin and bilistick with serum bilirubin in preterm infants receiving phototherapy

Rinawati Rohsiswatmo  1   2 , Hanifah Oswari  1 , Radhian Amandito  2 , Hikari Ambara Sjakti  1 , Endang Windiastuti  1 , Rosalina Dewi Roeslani  1 , Indrayady Barchia  3
Affiliations

Agreement test of transcutaneous bilirubin and bilistick with serum bilirubin in preterm infants receiving phototherapy

Rinawati Rohsiswatmo et al. BMC Pediatr. .

Abstract

Background: This study compares the minimally invasive Bilistick and a noninvasive method with standard Total Serum Bilirubin (TSB) measurement in preterm newborns receiving phototherapy. We assess the agreement of Transcutaneous Bilirubinometer (TcB) and Bilistick bilirubin measurements with standard TSB measurement in preterm infants receiving phototherapy.

Methods: Bilirubin was measured by using TcB and Bilistick in 94 preterm infants in RSCM Jakarta Neonatal Ward from October 2016 to March 2017, with gestational ages of < 35 weeks, before phototherapy and after 24 and 48 h of phototherapy.

Results: There was significant correlation before, at 24 and 48 h of phototherapy between TSB and either TcB (r = 0.874; r = 0.889; r = 0.878 respectively; p < 0.0001), or Bilistick (r = 0.868; r = 0.877; r = 0.918 respectively; p < 0.0001). The mean difference and limits of agreement before, at 24 and 48 h of phototherapy between TcB and TSB were 0.81 ± 1.51 mg/dL (- 2.14 to 3.77 mg/dL); 0.43 ± 1.57 mg/dL (- 2.66 to 3.51 mg/dL); 0.41 ± 1.58 mg/dL (- 2.69 to 3.50 mg/dL), respectively. For Bilistick they were - 1.50 ± 1.47 mg/dL (- 4.38 to 1.38 mg/dL); - 1.43 ± 1.47 mg/dL (- 4.32 to 1.46 mg/dL); - 1,15 ± 1.31 mg/dL (- 3,72 to 1,42 mg/dL), respectively.

Conclusions: Both methods are reliable for measuring TSB before, during, and after phototherapy in preterm infants. TcB tends to overestimate while Bilistick underestimates TSB.

Keywords: Bilistick; Indonesia; Phototherapy; Preterm infants; Transcutaneous bilirubin.

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Conflict of interest statement

Ethics approval and consent to participate

All authors hereby declare that all experiments have been examined and approved by the Ethics Committee of the Faculty of Medicine, Universitas Indonesia (No 783/UN2.F1/ETIK/2016) and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki. A written informed consent was provided by the parents of the children involved in the study.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Scatter and Bland Altman plot between TcB and TSB (a and b), Bilistick and TSB (c and d) before phototherapy, Y equation = linear equation obtained from linear regression analysis. Y = estimated TSB, X = Bilirubin level of the device being tested (formula image) = average difference (formula image) = agreement limit (formula image) = tendency of average difference (formula image) = 0 point, standard to observe distance with red line
Fig. 2
Fig. 2
Scatter and Bland Altman plots between TcB and TSB (a and b), Bilistick and TSB (c and d) at 24 h of phototherapy. Y equation = linear equation obtained from linear regression analysis. Y = estimated TSB, X = Bilirubin level of the device being tested (formula image) = average difference (formula image) = agreement limit (formula image) = tendency of average difference (formula image) = 0 point, standard to observe distance with red line
Fig. 3
Fig. 3
Scatter and Bland Altman plot between TcB and TSB (a and b), Bilistick and TSB (c and d) at 48 h of phototherapy. Y equation = linear equation obtained from linear regression analysis. Y = estimated TSB, X = Bilirubin level of the device being tested (formula image) = average difference (formula image) = agreement limit (formula image) = tendency of average difference (formula image) = 0 point, standard to observe distance with red line
See this image and copyright information in PMC

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