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Case Reports
. 2018 Sep-Oct;28(5):378-381.
doi: 10.4103/ijn.IJN_3_17.

Warfarin-related Nephropathy

Anvesh Golla  1 , R Goli  1 , V K Nagalla  1 , B V Kiran  1 , D S B Raju  1 , M S Uppin  2
Affiliations
Case Reports

Warfarin-related Nephropathy

Anvesh Golla et al. Indian J Nephrol. 2018 Sep-Oct.

Abstract

Warfarin-related nephropathy also referred to as anticoagulant-related nephropathy (ACRN) is a type of acute kidney injury (AKI) that may be caused by excessive anticoagulation with warfarin and other anticoagulants. Despite the well-described histological entity, the clinical course and approach to ACRN in patients requiring life-long anticoagulation are however not well described in the literature. We report a 50-year-old Indian woman who was on prolonged anticoagulant therapy post-mitral valve replacement. She presented with AKI, and renal biopsy was suggestive of ACRN. Steroids were given and her creatinine levels reached within the normal range in 2 weeks. A presumptive diagnosis of ACRN should be made if a severe warfarin coagulopathy is present and if other causes of AKI have been excluded, in patients with chronic anticoagulant therapy. Renal function should be monitored regularly in patients who are on anticoagulant therapy.

Keywords: Acute kidney injury; anticoagulant-related nephropathy; corticosteroids; mitral valve replacement; warfarin.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Renal biopsy findings: tubules show intraluminal red cell casts. Interstitium shows infiltrate of lymphocytes and neutrophils
See this image and copyright information in PMC

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