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Review
. 2018 Sep 8;9(18):3417-3426.
doi: 10.7150/jca.24591. eCollection 2018.

The Significance of Liquid Biopsy in Pancreatic Cancer

Zi-Hao Qi  1   2   3   4 , Hua-Xiang Xu  1   2   3   4 , Shi-Rong Zhang  1   2   3   4 , Jin-Zhi Xu  1   2   3   4 , Shuo Li  1   2   3   4 , He-Li Gao  1   2   3   4 , Wei Jin  1   2   3   4 , Wen-Quan Wang  1   2   3   4 , Chun-Tao Wu  1   2   3   4 , Quan-Xing Ni  1   2   3   4 , Xian-Jun Yu  1   2   3   4 , Liang Liu  1   2   3   4
Affiliations
Review

The Significance of Liquid Biopsy in Pancreatic Cancer

Zi-Hao Qi et al. J Cancer. .

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of cancer. The 5-year survival rate for PDAC remains low because it is always diagnosed at an advanced stage and it is resistant to therapy. A biomarker, which could detect asymptomatic premalignant or early malignant tumors and predict the response to treatment, will benefit patients with PDAC. However, traditional biopsy has its limitations. There is an urgent need for a tumor biomarker that could easily and repeatedly sample and monitor, in real time, the progress of tumor development. Liquid biopsy could be a tool to assess potential biomarkers. In this review, we focused on the latest discoveries and advancements of liquid biopsy technology in pancreatic cancer research and demonstrated how this technology is being used in clinical applications.

Keywords: Cell-free nucleic acid; Circulating tumor cells; Exosomes; Liquid biopsy; Pancreatic cancer.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
The difference between liquid biopsy and traditional biopsy.
See this image and copyright information in PMC

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