Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Sep 7:7:F1000 Faculty Rev-1429.
doi: 10.12688/f1000research.15081.1. eCollection 2018.

Recent advances in the understanding and management of mucormycosis

Benoit Pilmis  1   2 , Alexandre Alanio  3   4   5 , Olivier Lortholary  1   4   5 , Fanny Lanternier  1   4   5
Affiliations
Review

Recent advances in the understanding and management of mucormycosis

Benoit Pilmis et al. F1000Res. .

Abstract

Mucormycoses were difficult-to-manage infections owing to limited diagnostic tools and therapeutic options. We review here advances in pathology understanding, diagnostic tools including computed tomography, and serum polymerase chain reaction and therapeutic options.

Keywords: Isavuconazole; Liposomal amphotericin B; Mucormycosis; PCR; Reverse Halo sign.

PubMed Disclaimer

Conflict of interest statement

Competing interests: FL is a speaker for bureau Gilead, Basilea, MSD. Concultancy Basilea. She received research grant from Gilead Sciences. OL has been a consultant for Gilead Sciences, a speakers’ bureau for Pfeizer, Novartis, Astellas, Merck, and Gilead Sciences, and has received research grants from Gilead Sciences. AA has received travel grant from MSD, Gilead and Astella and honoraria from Pathoquest and Gilead outside the submitted work. BP has no competing interests to declare.No competing interests were disclosed.No competing interests were disclosed.

Figures

Figure 1.
Figure 1.. Typical features of Rhizopus arrhizus.
( a) Sporangiophore branching and rhizoids (stereomicroscope); ( b) grey-brownish colony on malt 2% medium; ( c) melanized sporangium and sporangiospores.
Figure 2.
Figure 2.. Inversed halo sign.
Inversed halo sign.
Figure 3.
Figure 3.. Mucormycosis: from suspicion to treatment.
PCR, polymerase chain reaction.
See this image and copyright information in PMC

References

    1. Roden MM, Zaoutis TE, Buchanan WL, et al. : Epidemiology and outcome of zygomycosis: a review of 929 reported cases. Clin Infect Dis. 2005;41(5):634–53. 10.1086/432579 - DOI - PubMed
    1. Alanio A, Desnos-Ollivier M, Garcia-Hermoso D, et al. : Investigating Clinical Issues by Genotyping of Medically Important Fungi: Why and How? Clin Microbiol Rev. 2017;30(3):671–707. 10.1128/CMR.00043-16 - DOI - PMC - PubMed
    1. Bitar D, Van Cauteren D, Lanternier F, et al. : Increasing incidence of zygomycosis (mucormycosis), France, 1997-2006. Emerg Infect Dis. 2009;15(9):1395–401. 10.3201/eid1509.090334 - DOI - PMC - PubMed

    2. F1000 Recommendation

    1. Guinea J, Escribano P, Vena A, et al. : Increasing incidence of mucormycosis in a large Spanish hospital from 2007 to 2015: Epidemiology and microbiological characterization of the isolates. PLoS One. 2017;12(6):e0179136. 10.1371/journal.pone.0179136 - DOI - PMC - PubMed

    2. F1000 Recommendation

    1. Bitar D, Lortholary O, Le Strat Y, et al. : Population-based analysis of invasive fungal infections, France, 2001-2010. Emerg Infect Dis. 2014;20(7):1149–55. 10.3201/eid2007.140087 - DOI - PMC - PubMed

    2. F1000 Recommendation

Substances

LinkOut - more resources