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Review
. 2018 Sep 28;6(3):306-309.
doi: 10.14218/JCTH.2018.00003. Epub 2018 May 4.

A Systematic Literature Review of Syphilitic Hepatitis in Adults

Jiaofeng Huang  1 , Su Lin  1 , Bo Wan  2 , Yueyong Zhu  1
Affiliations
Review

A Systematic Literature Review of Syphilitic Hepatitis in Adults

Jiaofeng Huang et al. J Clin Transl Hepatol. .

Abstract

Syphilitic hepatitis in adults is not frequently found in the population and is easily misdiagnosed. The incidence of viral hepatitis is increasing year by year, concomitantly increasing the importance of obtaining a systematic understanding of the clinical features and treatment strategies for this disease. There is, however, a lack of published definitive data regarding the clinical characteristics, diagnosis and standard treatment options for this disease. Searches were made using the MEDLINE database of PubMed and OVID for syphilitic hepatitis publications from 1951 to 2017 in an attempt to analyze and summarize the clinical characteristics.

Keywords: Granuloma; Hepatitis; Liver enzyme; Syphilis.

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Conflict of interest statement

The authors have no conflict of interests related to this publication.

Figures

Fig. 1.
Fig. 1.. A flow chart of the procedure followed for this systematic review.
Fig. 2.
Fig. 2.. The mean and 95% CI of laboratory values.
Abbreviations: ALP, alkaline phosphatase; ALT, alanine transaminase; AST, aspartate aminotransferase; CI, confidence interval; GGT, gamma-glutamyl transpeptidase; TBIL, total bilirubin.
See this image and copyright information in PMC

References

    1. Dupin N, Farhi D. Syphilis. Presse Med. 2013;42:446–453. doi: 10.1016/j.lpm.2012.09.024. - DOI - PubMed
    1. Suzuki I, Orfanidis N, Moleski S, Katz LC, Kastenberg D. The “great imitator” presents with abnormal liver enzymes. The Medicine Forum. 2009;11:17. doi: 10.29046/TMF.011.1.015. - DOI
    1. Sabbatani S, Manfredi R, Attard L, Chiodo F. The “great imitator” syphilis as causative agent of isolated, concurrent, acute hepatitis and meningitis. Infect Dis Clin Pract. 2005;13:261–264. doi: 10.1097/01.idc.0000168478.73470.69. - DOI
    1. Goodridge HF. A case of acute atrophy of the liver complicating early secondary syphilis. Br Med J. 1871;1:609–610. doi: 10.1136/bmj.1.545.609. - DOI - PMC - PubMed
    1. Keshtkar-Jahromi M, Rassaei N, Bruno MA, Maneval ML, Whitener CJ. Photo quiz. a 59-year-old man with multiple liver lesions, rash, and uveitis. Clin Infect Dis. 2016;62:82–83. doi: 10.1093/cid/civ754. - DOI - PubMed