doi: 10.1128/JVI.61.3.933-936.1987.
env-encoded residues are not required for transformation by p48v-myb
- PMID: 3027417
- PMCID: PMC254042
- DOI: 10.1128/JVI.61.3.933-936.1987
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env-encoded residues are not required for transformation by p48v-myb
J Virol.
1987 Mar.
Abstract
The v-myb oncogene of avian myeloblastosis virus induces acute myeloblastic leukemia in chickens and transforms avian myeloid cells in vitro. The protein product of this oncogene, p48v-myb, is partially encoded by the retroviral gag and env genes. We demonstrated that the env-encoded carboxyl terminus of p48v-myb is not required for transformation. Our results showed, in addition, that a coding region of c-myb which is not essential for transformation was transduced by avian myeloblastosis virus.
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