Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Sep 29;19(10):2974.
doi: 10.3390/ijms19102974.

TIPE Family of Proteins and Its Implications in Different Chronic Diseases

Devivasha Bordoloi  1 , Kishore Banik  2 , Bano Shabnam  3 , Ganesan Padmavathi  4 , Javadi Monisha  5 , Frank Arfuso  6 , Arunasalam Dharmarajan  7 , Xinliang Mao  8   9 , Lina H K Lim  10   11 , Lingzhi Wang  12   13 , Lu Fan  14 , Kam Man Hui  15 , Alan Prem Kumar  16   17   18   19 , Gautam Sethi  20 , Ajaikumar B Kunnumakkara  21
Affiliations
Review

TIPE Family of Proteins and Its Implications in Different Chronic Diseases

Devivasha Bordoloi et al. Int J Mol Sci. .

Abstract

The tumor necrosis factor-α-induced protein 8-like (TIPE/TNFAIP8) family is a recently identified family of proteins that is strongly associated with the regulation of immunity and tumorigenesis. This family is comprised of four members, namely, tumor necrosis factor-α-induced protein 8 (TIPE/TNFAIP8), tumor necrosis factor-α-induced protein 8-like 1 (TIPE1/TNFAIP8L1), tumor necrosis factor-α-induced protein 8-like 2 (TIPE2/TNFAIP8L2), and tumor necrosis factor-α-induced protein 8-like 3 (TIPE3/TNFAIP8L3). Although the proteins of this family were initially described as regulators of tumorigenesis, inflammation, and cell death, they are also found to be involved in the regulation of autophagy and the transfer of lipid secondary messengers, besides contributing to immune function and homeostasis. Interestingly, despite the existence of a significant sequence homology among the four members of this family, they are involved in different biological activities and also exhibit remarkable variability of expression. Furthermore, this family of proteins is highly deregulated in different human cancers and various chronic diseases. This review summarizes the vivid role of the TIPE family of proteins and its association with various signaling cascades in diverse chronic diseases.

Keywords: TIPE; TIPE1; TIPE2; TIPE3; cancer; chronic diseases.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Various chronic diseases associated with TIPE family of proteins.
Figure 2
Figure 2
Role of TIPE family of proteins and their molecular mechanisms in different chronic diseases; (A). Atherosclerosis, (B). Colitis, (C). Rheumatoid Arthritis, (D). Hepatitis B and C, (E). Liver Fibrosis, (F). Myasthenia Gravis, (G). Parkinson’s Disease, (H). Choroidal Neovascularization, (I). Diabetes, (J). Restenosis
See this image and copyright information in PMC

References

    1. Goldsmith J.R., Chen Y.H. Regulation of inflammation and tumorigenesis by the TIPE family of phospholipid transfer proteins. Cell. Mol. Immunol. 2017;14:482–487. doi: 10.1038/cmi.2017.4. - DOI - PMC - PubMed
    1. Shen P., Zhang H., Su Z., Wang S., Xu H. In Silico Analysis of Tumor Necrosis Factor α-Induced Protein 8-Like-1 (TIPE1) Protein. PLoS ONE. 2015;10:e0134114. doi: 10.1371/journal.pone.0134114. - DOI - PMC - PubMed
    1. Kim J.S., Park J., Kim M.S., Ha J.Y., Jang Y.W., Shin D.H., Son J.H. The Tnfaip8-PE complex is a novel upstream effector in the anti-autophagic action of insulin. Sci. Rep. 2017;7:6248. doi: 10.1038/s41598-017-06576-3. - DOI - PMC - PubMed
    1. Sullivan C., Lage C.R., Yoder J.A., Postlethwait J.H., Kim C.H. Evolutionary divergence of the vertebrate TNFAIP8 gene family: Applying the spotted gar orthology bridge to understand ohnolog loss in teleosts. PLoS ONE. 2017;12:e0179517. doi: 10.1371/journal.pone.0179517. - DOI - PMC - PubMed
    1. Padmavathi G., Banik K., Monisha J., Bordoloi D., Shabnam B., Arfuso F., Sethi G., Fan L., Kunnumakkara A.B. Novel tumor necrosis factor-α induced protein eight (TNFAIP8/TIPE) family: Functions and downstream targets involved in cancer progression. Cancer Lett. 2018;432:260–271. doi: 10.1016/j.canlet.2018.06.017. - DOI - PubMed

MeSH terms

Substances