Sexual Inequality in the Cancer Cell
- PMID: 30275051
- PMCID: PMC6204258
- DOI: 10.1158/0008-5472.CAN-18-2219
Sexual Inequality in the Cancer Cell
Abstract
Investigating sex differences in cancer will improve therapy for both sexes and discover sex-specific protective mechanisms. Two recent analyses by Lopes-Ramos and colleagues and Li and colleagues point to specific gene regulatory networks and genomic alterations associated with sex differences in tumor incidence and progression. Integrating this information with emerging concepts about sex biases in the genome may help focus attention on factors that shift the odds for tumor growth. Cancer Res; 78(19); 5504-5. ©2018 AACR See related articles by Li et al., p. 5527, and Lopes-Ramos et al., p. 5538.
©2018 American Association for Cancer Research.
Conflict of interest statement
Disclosure of Potential Conflicts of Interest
No potential conflicts of interest were disclosed.
Comment on
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Sex Differences in Cancer Driver Genes and Biomarkers.Cancer Res. 2018 Oct 1;78(19):5527-5537. doi: 10.1158/0008-5472.CAN-18-0362. Cancer Res. 2018. PMID: 30275052
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Gene Regulatory Network Analysis Identifies Sex-Linked Differences in Colon Cancer Drug Metabolism.Cancer Res. 2018 Oct 1;78(19):5538-5547. doi: 10.1158/0008-5472.CAN-18-0454. Cancer Res. 2018. PMID: 30275053 Free PMC article.
References
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- Li C, Haider S, Shiah Y-J, Thai K, Boutros PC. Sex differences in cancer driver genes and biomarkers. Cancer Res 2018. In press. - PubMed
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- Veitia RA, Veyrunes F, Bottani S, Birchler JA. X chromosome inactivation and active X upregulation in therian mammals: facts, questions, and hypotheses. J Mol Cell Biol 2015;7:2–11. - PubMed
