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. 2018 Oct 1;6(4):52.
doi: 10.3390/dj6040052.

Effects of Amorphous Calcium Phosphate Administration on Dental Sensitivity during In-Office and At-Home Interventions

Giacomo Oldoini  1 , Antonino Bruno  2 , Anna Maria Genovesi  3 , Luca Parisi  4
Affiliations

Effects of Amorphous Calcium Phosphate Administration on Dental Sensitivity during In-Office and At-Home Interventions

Giacomo Oldoini et al. Dent J (Basel). .

Abstract

Background: Tooth bleaching is the most frequently employed whitening procedure in clinics. The major side effect of tooth bleaching is dental sensitivity during and after the treatment. Here, we evaluated whether the administration of amorphous calcium phosphate (ACP), during in-office and at-home procedures may impact on dental sensitivity.

Methods: Eighty patients, responding to the study requirements were enrolled according to the following criteria. Group 1 (n = 40), received in-office, 10% ACP prior to 30% professional hydrogen peroxide application. The whitening procedure continued at home using 10% carbamide peroxide with 15% ACP for 15 days. Group 2 (n = 40) received only 30% hydrogen peroxide application and continued the whitening procedures at home, using 10% carbamide hydroxide, without ACP- Casein phosphopeptides (CPP), for 15 days. Dental sensitivity was recorded with a visual analogue scale (VAS) at baseline, immediately after, and at 15 days after treatment in the two groups.

Results: We observed that patients receiving ACP in the bleaching mixture experienced decreased dental sensitivity (* p ≤ 0.05), as detected by VAS scale analysis immediately following the procedures. Patients receiving ACP-CPP during at-home procedures showed a statistically significant (*** p ≤ 0.0001) reduction of dental sensitivity.

Conclusions: We demonstrated that ACP-CPP administration, while exerting the same whitening effects as in control subjects receiving potassium fluoride (PF), had an impact on the reduction of dental sensitivity, improving patient compliance.

Keywords: amorphous calcium phosphate; at-home procedures; dental sensitivity; in-office procedures; tooth bleaching.

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Conflict of interest statement

We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome.

Figures

Figure 1
Figure 1
Effects of ACP-CPP combination on dental sensitivity, following in-office oral hygiene procedures. ACP-CPP treatment significantly reduced dental sensitivity, as compared to the control group (PF), immediately after treatment (T1). Results are showed as mean ± SEM, * p ≤ 0.05.
Figure 2
Figure 2
Effects of ACP-CPP combination on dental sensitivity, following at-home oral hygiene procedures. ACP-CPP treatment significantly reduced dental sensitivity as compared to control (PF) group, during the following 15 (T15) days. Results are showed as mean ± SEM, *** p ≤ 0.0001.
Figure 3
Figure 3
Effects of ACP-CPP administration on dental sensitivity, following at-home oral hygiene procedures as related to smoking habits. ACP-CPP treatment resulted in decreased dental sensitivity, as compared with the control (PF) group, both in non-smoker and smoker patients. Results are showed as mean ± SEM, ** p ≤ 0.01; *** p ≤ 0.0001.
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