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Review
. 2018 Sep 7;15(12):1415-1422.
doi: 10.7150/ijms.26741. eCollection 2018.

Role of TCF/LEF Transcription Factors in Bone Development and Osteogenesis

Zhengqiang Li  1   2 , Zhimin Xu  1   3 , Congcong Duan  1   3 , Weiwei Liu  1   3 , Jingchun Sun  1   3 , Bing Han  1   3
Affiliations
Review

Role of TCF/LEF Transcription Factors in Bone Development and Osteogenesis

Zhengqiang Li et al. Int J Med Sci. .

Abstract

Bone formation occurs by two distinct mechanisms, namely, periosteal ossification and endochondral ossification. In both mechanisms, osteoblasts play an important role in the secretion and mineralization of bone-specific extracellular matrix. Differentiation and maturation of osteoblasts is a prerequisite to bone formation and is regulated by many factors. Recent experiments have shown that transcription factors play an important role in regulating osteoblast differentiation, proliferation, and function. Osteogenesis related transcription factors are the central targets and key mediators of the function of growth factors, such as cytokines. Transcription factors play a key role in the transformation of mesenchymal progenitor cells into functional osteoblasts. These transcription factors are closely linked with each other and in conjunction with bone-related signaling pathways form a complex network that regulates osteoblast differentiation and bone formation. In this paper, we discuss the structure of T-cell factor/lymphoid enhancer factor (TCF/LEF) and its role in embryonic skeletal development and the crosstalk with related signaling pathways and factors.

Keywords: Osteogenesis; TCF/LEF Transcription Factors; signal transduction pathway.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Fig 1
Fig 1
The structural domains of TCF/LEF.
Fig 2
Fig 2
The crosstalk of TCF/LEF between the signaling pathways.
See this image and copyright information in PMC

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