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Review
. 2016 Apr-Jun;2(2):67-71.
doi: 10.4103/2394-8108.186260. Epub 2016 Jul 13.

Rationale for ischemic conditioning to prevent stroke in patients with intracranial arterial stenosis

Sami Al Kasab  1 , David C Hess  2 , Marc I Chimowitz  1
Affiliations
Review

Rationale for ischemic conditioning to prevent stroke in patients with intracranial arterial stenosis

Sami Al Kasab et al. Brain Circ. 2016 Apr-Jun.

Abstract

Intracranial atherosclerotic arterial stenosis (ICAS) is one of the most common causes of stroke worldwide and is associated with particularly a high risk of recurrent stroke. Although aggressive medical management, consisting of dual antiplatelet therapy and intensive control of vascular risk factors, has improved the prognosis of patients with ICAS, subgroups of patients remain at very high risk of stroke. More effective therapies for these high-risk patients are urgently needed. One promising treatment is remote limb ischemic conditioning, which involves producing repetitive, transient ischemia of a limb by inflating a blood pressure cuff with the intention of protecting the brain from subsequent ischemia. In this study, we review the limitations of currently available treatments, discuss the potential mechanisms of action of ischemic conditioning, describe the preclinical and clinical data suggesting a possible role of ischemic conditioning in treating patients with ICAS, and outline the questions that still need to be answered in future studies of ischemic conditioning in subjects with ICAS.

Keywords: Intracranial atherosclerosis; ischemic conditioning; stroke.

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Conflict of interest statement

There are no conflicts of interest.

References

    1. Sacco RL, Kargman DE, Gu Q, Zamanillo MC. Race-ethnicity and determinants of intracranial atherosclerotic cerebral infarction. The Northern Manhattan Stroke Study. Stroke. 1995;26:14–20. - PubMed
    1. Qureshi AI, Safdar K, Patel M, Janssen RS, Frankel MR. Stroke in young black patients. Risk factors, subtypes, and prognosis. Stroke. 1995;26:1995–8. - PubMed
    1. Weisberg LA. Clinical characteristics of transient ischemic attacks in black patients. Neurology. 1991;41:1410–4. - PubMed
    1. Wityk RJ, Lehman D, Klag M, Coresh J, Ahn H, Litt B. Race and sex differences in the distribution of cerebral atherosclerosis. Stroke. 1996;27:1974–80. - PubMed
    1. Feldmann E, Daneault N, Kwan E, Ho KJ, Pessin MS, Langenberg P, et al. Chinese-white differences in the distribution of occlusive cerebrovascular disease. Neurology. 1990;40:1541–5. - PubMed