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Comment
. 2019 May;69(5):2300.
doi: 10.1002/hep.30298.

Letter to Editor: Response to AASLD Editorial/Message from the President

Ronald L Koretz  1 , Janus C Jakobsen  2   3 , Goran Hauser  4 , Dimitrinka Nikolova  2 , Christian Gluud  2
Affiliations
Comment

Letter to Editor: Response to AASLD Editorial/Message from the President

Ronald L Koretz et al. Hepatology. 2019 May.

Abstract

A commentary [1] criticized our systematic review regarding the use of direct-acting agents (DAAs) in chronic hepatitis C [2]. The following represents our major disagreements. Sustained virological response (SVR) is a non-validated surrogate outcome. The principles of evidence-based medicine require that it be validated in randomized clinical trials (RCTs) by showing parallel benefits in clinical outcomes [3]. This article is protected by copyright. All rights reserved.

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Comment in

  • Reply.
    Lok AS, Powderly WG. Lok AS, et al. Hepatology. 2019 May;69(5):2301. doi: 10.1002/hep.30564. Hepatology. 2019. PMID: 30762891

Comment on

  • Comments on cochrane review on direct-acting antivirals for hepatitis C.
    Lok AS, Chung RT, Vargas HE, Kim AY, Naggie S, Powderly WG. Lok AS, et al. Hepatology. 2017 Oct;66(4):1016-1019. doi: 10.1002/hep.29366. Epub 2017 Aug 26. Hepatology. 2017. PMID: 28714142 No abstract available.
  • Direct-acting antivirals for chronic hepatitis C.
    Jakobsen JC, Nielsen EE, Feinberg J, Katakam KK, Fobian K, Hauser G, Poropat G, Djurisic S, Weiss KH, Bjelakovic M, Bjelakovic G, Klingenberg SL, Liu JP, Nikolova D, Koretz RL, Gluud C. Jakobsen JC, et al. Cochrane Database Syst Rev. 2017 Sep 18;9(9):CD012143. doi: 10.1002/14651858.CD012143.pub3. Cochrane Database Syst Rev. 2017. PMID: 28922704 Free PMC article.

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