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Meta-Analysis
. 2019 Oct;13(5):1021-1031.
doi: 10.1111/eip.12749. Epub 2018 Oct 2.

Glucose metabolism dysregulation at the onset of mental illness is not limited to first episode psychosis: A systematic review and meta-analysis

Suat Kucukgoncu  1 , Urska Kosir  1 , Elton Zhou  1 , Erin Sullivan  1 , Vinod H Srihari  1 , Cenk Tek  1
Affiliations
Meta-Analysis

Glucose metabolism dysregulation at the onset of mental illness is not limited to first episode psychosis: A systematic review and meta-analysis

Suat Kucukgoncu et al. Early Interv Psychiatry. 2019 Oct.

Abstract

Aim: To compare the differences of glucose metabolism outcomes between treatment-naïve, patients with first episode psychosis (FEP) and mood disorders.

Methods: We conducted a systematic review and meta-analysis of glucose intolerance in treatment-naïve, first episode patients with severe mental illnesses (SMIs).

Results: We identified 31 eligible studies. Compared to healthy controls, FEP group have higher insulin and insulin resistance levels, and both groups have higher glucose tolerance test results. No significant differences were found in glucose metabolism outcomes between FEP and mood disorder groups.

Conclusions: Our results highlight impaired glucose metabolism at the onset of SMIs, suggesting both patients with psychosis and mood disorders are high-risk groups for diabetes development.

Keywords: diabetes; first episode; insulin; mood disorders; psychosis.

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Figures

Figure 1.
Figure 1.
PRISMA Flow Diagram
Figure 2.
Figure 2.
Meta-analysis of fasting blood glucose levels in first episode patients Heterogeneity: Tau2=0.07; I2=57.35%; Q=72.69, d.f=31, p<0.001 Overall effect (Fixed): Z=2.977, p=0.003 Overall effect (Random): Z=1.474, p=0.14 Dx: Diagnoses. 1=First episode psychosis, 2=First episode depression, 3=First episode bipolar disorder
Figure 3.
Figure 3.
Meta-analysis of insulin levels in first episode patients Heterogeneity: Tau2=0.19; I2=76.52%; Q=76.66, d.f= 18, p<0.001 Overall effect (Fixed): Z=4.148, p<0.001 Overall effect: Z=0.092, p=0.35 Dx: Diagnoses. 1=First episode psychosis, 2=First episode depression, 3=First episode bipolar disorder
Figure 4.
Figure 4.
Meta-analysis of insulin resistance in first episode patients Heterogeneity: Tau2=0.047; I2=47.61%; Q=28.63, d.f=15, p=0.018 Overall effect (Fixed): Z=5.34, p<0.001 Overall effect (Random): Z=1.451, p=0.14 Dx: Diagnoses. 1=First episode psychosis, 2=First episode depression, 3=First episode bipolar disorder
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