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Meta-Analysis
. 2018 Sep;97(39):e11863.
doi: 10.1097/MD.0000000000011863.

Prevalence and determinants of depression in caregivers of cancer patients: A systematic review and meta-analysis

Hai-Mei Geng  1 , Dong-Mei Chuang  2 , Fang Yang  1 , Yang Yang  1 , Wei-Min Liu  1 , Li-Hui Liu  3 , Hong-Mei Tian  3
Affiliations
Meta-Analysis

Prevalence and determinants of depression in caregivers of cancer patients: A systematic review and meta-analysis

Hai-Mei Geng et al. Medicine (Baltimore). 2018 Sep.

Abstract

Background: Aim of this study was to estimate the prevalence rate of depression in cancer patient caregivers and to identify factors affecting depression and quality of life of cancer caregivers.

Methods: Relevant research articles were retrieved after literature search in several electronic databases. Random effects meta-analyses were performed to obtain pooled estimates of the prevalence rates of depression and anxiety; their respective scores, and quality of life scores. Significant relationships between depression and factors related to depression and quality of life reported in individual studies were identified.

Results: Thirty studies were included. Overall, 21,149 caregivers were appraised in these studies (age 52.65 years [95% CI: 49.65, 55.65]; 31.14% [28.40, 33.89] men). The prevalence of depression and anxiety were 42.30% [33.31, 51.29] % and 46.55% [35.59, 57.52], respectively. Quality of life score, as measured with Caregiver Quality of Life-Cancer scale was 64.55 [47.44, 81.66]. Patient's condition, caregiving burden, duration of caregiving, spouse caregiver, caregiver being unemployed, caregiver with chronic disease, caregiver's sleep quality, caregiver's avoidance, financial problems, and female sex were positively associated with depression whereas overall quality of life of caregiver, pre-loss grief, caregiver's education level, caregiver's age, caregiver's sense of coherence, and caregiver's bondage with patient were negatively associated with depression in caregivers.

Conclusion: A considerably high prevalence of depression is found in cancer patient caregivers. Several factors may affect depression and their quality of life of cancer patient caregivers.

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Figures

Figure 1
Figure 1
A flowchart of study screening and selection process.
Figure 2
Figure 2
Forest graphs showing the pooled estimates of (A) the prevalence rates of depression with regards to psychometric tools used in the included studies; and (B) the depression scores.
Figure 2 (Continued)
Figure 2 (Continued)
Forest graphs showing the pooled estimates of (A) the prevalence rates of depression with regards to psychometric tools used in the included studies; and (B) the depression scores.
Figure 3
Figure 3
A forest graph showing the pooled estimates of the quality of life score, as measured with Caregiver Quality of Life—Cancer scale.
See this image and copyright information in PMC

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