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Meta-Analysis
. 2018 Sep;97(39):e12456.
doi: 10.1097/MD.0000000000012456.

Treatment with normobaric or hyperbaric oxygen and its effect on neuropsychometric dysfunction after carbon monoxide poisoning: A systematic review and meta-analysis of randomized controlled trials

Chun-Hung Lin  1 , Wei-Haiang Su  2 , Ying-Chun Chen  3 , Po-Hao Feng  4   5 , Wan-Chen Shen  3 , Jiann-Ruey Ong  6   7 , Mei-Yi Wu  5   8   9 , Chung Shun Wong  6   7   10
Affiliations
Meta-Analysis

Treatment with normobaric or hyperbaric oxygen and its effect on neuropsychometric dysfunction after carbon monoxide poisoning: A systematic review and meta-analysis of randomized controlled trials

Chun-Hung Lin et al. Medicine (Baltimore). 2018 Sep.

Abstract

Background: Carbon monoxide (CO) poisoning may result in acute neurological sequelae, cognitive sequelae, and delay neurological sequelae. The administration of hyperbaric oxygen (HBO) to prevent the development of delayed neurological sequelae in CO poisoning have extensively investigated but conflicting results have been reported. We performed a systematic literature review and meta-analysis of randomized controlled trials (RCTs) evaluating HBO treatment and its effect on neuropsychometric dysfunction after CO poisoning.

Methods: We searched Medline, Embase, Pubmed, and the Cochrane Register of Controlled Trials from inception to December 2017. Eligible studies compared HBO therapy with normobaric oxygen (NBO) in patients with CO poisoning.

Results: Six studies compared HBO with NBO in CO poisoning patients. Compared with patients treated with NBO, a lower percentage of patients treated with HBO reported headache (16.2% vs 16.5%, relative risk [RR] = 0.83, 95% CI = 0.38-1.80), memory impairment (18.2% vs 23.8%, RR = 0.80, 95% CI = 0.43-1.49), difficulty concentrating (15.0% vs 18.4%, RR = 0.86, 95% CI = 0.55-1.34), and disturbed sleep (14.7% vs 16.2%, RR = 0.91, 95% CI = 0.59-1.39). Two sessions of HBO treatment exhibited no advantage over one session.

Conclusions: The meta-analysis indicated that compared with CO poisoning patients treated with NBO, HBO treated patients have a lower incidence of neuropsychological sequelae, including headache, memory impairment, difficulty concentrating, disturbed sleep, and delayed neurological sequelae. Taking into consideration the cost-effectiveness of one session of HBO, one session of HBO treatment could be an economical option for patients with CO poisoning with high severity.

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Figures

Figure 1
Figure 1
Flowchart for selection of studies—PRISMA flow diagram.
Figure 2
Figure 2
Forest plot for comparison of hyperbaric oxygen versus normobaric oxygen. Outcome: incidence of neuropsychological sequelae.
Figure 3
Figure 3
Forest plot for comparison of 2 sessions versus one session of hyperbaric oxygen treatment. Outcome: incidence of neuropsychological sequelae.
See this image and copyright information in PMC

References

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