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Review
. 2018 Sep;97(39):e12489.
doi: 10.1097/MD.0000000000012489.

Relationship between short telomere length and stroke: A meta-analysis

Xiao Jin  1 , Biqi Pan  2 , Xiaojing Dang  3 , Huanlin Wu  4 , Danping Xu  3
Affiliations
Review

Relationship between short telomere length and stroke: A meta-analysis

Xiao Jin et al. Medicine (Baltimore). 2018 Sep.

Abstract

Background: Several epidemiological studies had been carried out in different population cohorts to estimate the relationship between the shortened telomere length and stroke. However, the results still remained dispute. Consequently, we conducted this meta-analysis to estimate the relationship between them.

Methods: PubMed, EMBASE, and Web of Science were systematically searched for related articles to evaluate the association between "stroke" and "telomere length. STATA 12.0 software was used to perform the meta-analysis. The Cochran Q test and inconsistency index (I) were used to assess the heterogeneity. Begg funnel plot and Egger test were used to assess publication bias.

Results: The meta-analysis was composed of 11 studies, consisting of 25,340 participants. We found a significant relationship between shortened telomere length and stroke (OR: 1.50, 95% CI: 1.13-2.0; P = .005); however, in the prospective and retrospective study subgroup, we did not find a statistical significant relationship between shortened telomere length and stroke (the prospective subgroup: OR: 1.41, 95% CI: 1-1.98; P = .051) (the retrospective subgroup: OR: 1.89, 95% CI: 0.96-3.72; P = .067).

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Flow chart for the process of selecting eligible publications.
Figure 2
Figure 2
Meta-analysis of the association between telomere length and stroke.
Figure 3
Figure 3
Sensitivity analyses of selected studies.
Figure 4
Figure 4
Begg funnel plot with pseudo 95% CIs.
See this image and copyright information in PMC

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