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. 1987 Jan;13(1):93-7.
doi: 10.1007/BF02422304.

Assignment of mouse beta-spectrin gene to chromosome 12

P Laurila, L Cioe, C A Kozak, P J Curtis

Assignment of mouse beta-spectrin gene to chromosome 12

P Laurila et al. Somat Cell Mol Genet. 1987 Jan.

Abstract

The structural gene for the beta-subunit of the mouse erythrocyte spectrin, hereinafter designated as Sp-b, was assigned to the mouse chromosome 12. This assignment was made by Southern analysis of genomic DNA from mouse X Chinese hamster hybrid cells using cloned mouse erythrocyte beta-spectrin cDNA as a probe. In the PstI-digested genomic hamster cell DNA a single band of 2.0 kb was detected, whereas PstI-digested mouse DNA gave a band of 4.2 kb, when probed with the mouse erythroid beta-spectrin cDNA clone. This allowed us to analyze a panel of mouse X Chinese hamster somatic cell hybrids to map this gene to chromosome 12. Interestingly, this assignment is different from that observed for the alpha-subunit of spectrin, which has been mapped to chromosome 1 in mouse. These results serve as a basis for further genetic characterization of the mouse hemolytic anemias.

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