Blood-Based Prediction of Tumor Relapse: The cfDNA Forecast
- PMID: 30279194
- DOI: 10.1158/2159-8290.CD-18-0952
Blood-Based Prediction of Tumor Relapse: The cfDNA Forecast
Abstract
Khan and colleagues demonstrate how serial blood-based liquid biopsies integrated with imaging and mathematical modeling can accurately "forecast" the time to treatment failure in patients with metastatic colorectal cancer treated with EGFR blockade, by early detection of molecular alterations associated with drug resistance in cell-free DNA. Cancer Discov; 8(10); 1213-5. ©2018 AACR See related article by Khan et al., p. 1270.
©2018 American Association for Cancer Research.
Comment on
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Longitudinal Liquid Biopsy and Mathematical Modeling of Clonal Evolution Forecast Time to Treatment Failure in the PROSPECT-C Phase II Colorectal Cancer Clinical Trial.Cancer Discov. 2018 Oct;8(10):1270-1285. doi: 10.1158/2159-8290.CD-17-0891. Epub 2018 Aug 30. Cancer Discov. 2018. PMID: 30166348 Free PMC article. Clinical Trial.
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