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Case Reports
. 2018 Oct 2:2018:bcr2018226092.
doi: 10.1136/bcr-2018-226092.

Diabetic ketoalkalosis: misnomer or undiagnosed variant of diabetic ketoacidosis

Affiliations
Case Reports

Diabetic ketoalkalosis: misnomer or undiagnosed variant of diabetic ketoacidosis

Sushant Nanavati et al. BMJ Case Rep. .

Abstract

Usually, hyperglycaemia crisis presents with acidotic pH, but ketoalkalosis is a rare and unheard entity presenting in diabetic ketoacidosis. We describe three unique cases where the patients present with hyperglycaemia >250 mg/dL, normal or alkalotic pH, and bicarbonate >20 meq/L, which does not meet criteria for diabetic ketoacidosis. However, once these patients were supplemented with intravenous fluids, diagnosis of diabetic ketoacidosis was evident in laboratory analysis. These case series provide a learning opportunity in diagnosing and management of this rare phenomenon.

Keywords: adult intensive care; diabetes; fluid electrolyte and acid-base disturbances; metabolic disorders.

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Conflict of interest statement

Competing interests: None declared.

References

    1. Kumar V, Nanavati SM, Komal F, et al. . Ketoalkalosis: Masked Presentation of Diabetic Ketoacidosis With Literature Review. J Endocrinol Metab 2017;7:194–6. doi:10.14740/jem472w - DOI
    1. Bleicher S. Ketosis not always acidosis: ‘‘heartburn’’ can be relevant. Diabetes 1967;2:3–4.
    1. Huggins EA, Chillag SA, Rizvi AA, et al. . Diabetic ketoalkalosis in children and adults. South Med J 2014;107:6–10. 10.1097/SMJ.0000000000000040 - DOI - PubMed
    1. Kamel KS, Halperin ML. Acid-base problems in diabetic ketoacidosis. N Engl J Med 2015;372:546–54. 10.1056/NEJMra1207788 - DOI - PubMed
    1. Elisaf MS, Tsatsoulis AA, Katopodis KP, et al. . Acid-base and electrolyte disturbances in patients with diabetic ketoacidosis. Diabetes Res Clin Pract 1996;34:23–7. 10.1016/S0168-8227(96)01332-0 - DOI - PubMed

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