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Review
. 2018;22(3):280-283.
doi: 10.34763/devperiodmed.20182203.280283.

Cortisol deficiency as a rare cause of neonatal cholestasis

Patryk Lipiński  1 , Karolina Kot  2 , Irena Jankowska  1 , Mieczysław Szalecki  3
Affiliations
Review

Cortisol deficiency as a rare cause of neonatal cholestasis

Patryk Lipiński et al. Dev Period Med. 2018.

Abstract

Cortisol deficiency constitutes a rare cause of neonatal cholestasis. The aim of this manuscript was to present the pathogenesis of cortisol deficiency in neonatal cholestasis. The authors also present the characteristics of selected disorders resulting in cortisol deficiency.

Keywords: cholestasis; cortisol; familial glucocorticoid deficiency; multiple pituitary hormone deficiency; pituitary stalk interruption syndrome.

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Conflict of interest statement

Conflicts of interest

Konflikt interesu/Conflicts of interest

Autorzy pracy nie zgłaszają konfliktu interesów.

The Authors declare no conflict of interest.

Figures

Ryc. 1
Ryc. 1
Schemat transportu kwasów żółciowych [25, opublikowano za zgodą autora]. Objaśnienia: AL – aminofosfolipidy, PC – fosfatydylocholina, BA – kwasy żółciowe, OA – aniony organiczne, FIC1 – pompa odpowiadająca za przezbłonowy transport amino-fosfolipidów, BSEP – pompa eksportująca sole kwasów żółciowych, MDR3 – przenośnik fosfatydylocholiny, MRP2 – pompa transportująca kwasy żółciowe do krążenia ogólnego. Fig. 1. Schematic presentation of bile acid transport [25]. AL – aminophospholipids, PC – phosphatidylocholine, BA – bile acids, OA – organic anions, FIC1 – aminophospholipid transporter, BSEP – bile salt export pump, MDR3 – multidrug resistance protein 3, MRP2 – multidrug resistance associated protein.
See this image and copyright information in PMC

References

    1. Fawaz R, Baumann U, Ekong U, Fischler B, Hadzic N, Mack CL. Guideline for the Evaluation of Cholestatic Jaundice in Infants: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition and the European Society for Pediatric Gastroenterology. Hepatology and Nutrition. J Pediatr Gastroenterol Nutr. 2017;64:154–168. et al. - PubMed
    1. Wada K, Kobayashi H, Moriyama A, Haneda Y, Mushimoto Y, Hasegawa Y, i wsp.. A case of an infant with congenital combined pituitary hormone deficiency and normalized liver histology of infantile cholestasis after hormone replacement therapy. Clin Pediatr Endocrinol. 2017;26:251–257. - PMC - PubMed
    1. Alsaleem M, Saadeh L, Misra A, Madani S. Neonatal isolated ACTH deficiency (IAD): a potentially life-threatening but treatable cause of neonatal cholestasis. BMJ Case Rep. 2016;2016 pii: bcr2016215032. - PMC - PubMed
    1. Al-Hussaini A, Almutairi A, Mursi A, Alghofely M, Asery A.. Isolated cortisol deficiency: a rare cause of neonatal cholestasis. Saudi J Gastroenterol. 2012;18:339–341. - PMC - PubMed
    1. Mauvais FX, Gonzales E, Davit-Spraul A, Jacquemin E, Brauner R. Cholestasis reveals severe cortisol deficiency in neonatal pituitary stalk interruption syndrome. PLoS ONE. 2016;11:e0147750. doi: 10.1371/journal.pone.0147750. - DOI - PMC - PubMed