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Observational Study
. 2018 Nov;111(5):648-653.
doi: 10.5935/abc.20180166. Epub 2018 Sep 21.

Prognostic Differences between Men and Women with Acute Coronary Syndrome. Data from a Brazilian Registry

[Article in English, Portuguese]
Alexandre de Matos Soeiro  1 , Pedro Gabriel Melo de Barros E Silva  2 , Eduardo Alberto de Castro Roque  3 , Aline Siqueira Bossa  1 , Bruno Biselli  1 , Tatiana de Carvalho Andreucci Torres Leal  1 , Maria Carolina Feres de Almeida Soeiro  1 , Fábio Grunspun Pitta  1 , Carlos V Serrano Jr  1 , Múcio Tavares Oliveira Jr  1
Affiliations
Observational Study

Prognostic Differences between Men and Women with Acute Coronary Syndrome. Data from a Brazilian Registry

[Article in English, Portuguese]
Alexandre de Matos Soeiro et al. Arq Bras Cardiol. 2018 Nov.

Abstract

Background: Gender-related differences have been reported in patients with acute coronary syndrome. The description of this comparative finding in a Brazilian registry has not yet been documented.

Objective: To compare male vs. female patients regarding the baseline characteristics, coronary findings, treatment and in-hospital and long-term prognosis.

Methods: This is a retrospective, multicenter and observational study that included 3,745 patients (2,437 males and 1,308 females) between May 2010 and May 2015. The primary in-hospital outcome was all-cause mortality. The secondary outcome consisted of combined events (cardiogenic shock, reinfarction, death, stroke and bleeding). The comparison between groups was performed using the chi-square and the t test, considering p < 0.05 as significant. In the long term, mortality and combined events were assessed using the Kaplan-Meier method, with a mean follow-up of 8.79 months.

Results: The mean age was 60.3 years for males and 64.6 for females (p < 0.0001). The most prevalent risk factor was systemic arterial hypertension in 72.9% of the women and 67.8% of the men (p = 0.001). Percutaneous coronary intervention was carried out in 44.9% of the males and 35.4% of the females (p < 0.0001), and coronary artery bypass grafting (CABG) was performed in 17% of the males and 11.8% of females (p < 0.0001), with a higher prevalence of three-vessel coronary artery disease in males (27.3% vs. 16.2%, p < 0.0001). Approximately 79.9% of the female patients received a diagnosis of acute coronary syndrome without ST-segment elevation, while in the male patients, this diagnosis was attained in 71.5% (p < 0.0001). No significant differences were observed between the groups in the short and long term, regarding both mortality and the combined events.

Conclusion: Several gender-related differences were observed in patients with acute coronary syndrome regarding the demographic characteristics, coronary artery disease pattern and implemented treatment. However, the prognostic evolution was similar between the groups.

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Conflict of interest statement

Potential Conflict of Interest

No potential conflict of interest relevant to this article was reported.

Figures

Figure 1
Figure 1
Event-free survival and percentage of combined events in the medium-term comparison between males and females.
See this image and copyright information in PMC

Comment in

References

    1. Radovanovic D, Erne P, Urban P, Bertel O, Rickli H, Gaspoz JM. Gender differences in management and outcomes in patients with acute coronary syndromes: results on 20,290 patients from the AMIS Plus Registry. Heart. 2007;93(11):1369–1375. - PMC - PubMed
    1. Mehta LS, Beckie TM, DeVon HA, Grines CL, Krumholz HM, Johnson MN, et al. Acute Myocardial Infarction in Women: A Scientific Statement From the American Heart Association. Circulation. 2016;133(9):916–947. - PubMed
    1. Nicolau JC, Timerman A, Marin-Neto JA, Piegas LS, Barbosa CJDG, Franci A, et al. Sociedade Brasileira de Cardiologia. Diretrizes da Sociedade Brasileira de Cardiologia sobre angina instável e infarto agudo do miocárdio sem supradesnível do segmento ST. Arq Bras Cardiol. 2014;102(3) supl.1:1–61. - PubMed
    1. Jneid H, Anderson JL, Wright RS, Adams CD, Bridges CR, Casey DE, et al. 2012 ACCF/AHA focused update of the guideline for the management of patients with unstable angina/non-ST-elevation myocardial infarction (updating the 2007 guideline and replacing the 2011 focused update): a report ofthe American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2012;126(7):875–910. - PubMed
    1. Pendyala LK, Torguson R, Loh JP, Kitabata H, Minha S, Badr S, et al. Comparison of adverse outcomes after contemporary percutaneous coronary intervention in women versus men with acute coronary syndrome. Am J Cardiol. 2013;111(8):1092–1098. - PubMed

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