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Review
. 2018 Sep 19:9:981.
doi: 10.3389/fphar.2018.00981. eCollection 2018.

Bone Health and Natural Products- An Insight

Vasanti Suvarna  1 , Megha Sarkar  1 , Pramila Chaubey  1 , Tabassum Khan  1 , Atul Sherje  1 , Kavitkumar Patel  1 , Bhushan Dravyakar  1
Affiliations
Review

Bone Health and Natural Products- An Insight

Vasanti Suvarna et al. Front Pharmacol. .

Abstract

Bone metabolism involves a complex balance between matrix deposition, mineralization, and resorption. Numerous evidences have revealed that dietary components and phytoconstituents can influence these processes, through inhibition of bone resorption, thus exhibiting beneficial effects on the skeleton. Various traditional herbal formulae in ayurvedic and Chinese medicine have shown demonstrable benefits in pharmacological models of osteoporosis. The present review discusses normal bone metabolism and disorders caused by bone disruption, with particular reference to osteoporosis and current therapeutic treatment. Furthermore the effects of constituents from natural products on bone tissue are explained, with relevant evidences of efficacy in various experimental models.

Keywords: bone disorders; osteoblast; osteoclast; osteoporosis; phytochemicals.

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Figures

FIGURE 1
FIGURE 1
Phytochemicals and their mechanisms intervening various pathways in osteoporosis.
FIGURE 2
FIGURE 2
Chemical structures of phytochemicals with antiosteoporotic activity.
See this image and copyright information in PMC

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